ArticleMolecules (Basel, Switzerland)2020
Modulation of Lipid Metabolism by Trans-Anethole in Hepatocytes.
Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 19 citations in OpenAlex.
- Digestibility and transcriptomic profiling of kidney, pancreas, follicle, and uterus in laying hens supplemented with phytogenic feed additive.Poultry science · 2026Article
- Effects of Dietary Anise (Pimpinella anisum L.) Oil on Growth Performance, Blood Parameters and Muscle Nutrient Content of Nile Tilapia (Oreochromis niloticus).Veterinary medicine and science · 2025Article
- A comprehensive review of the neurological effects of anethole.IBRO neuroscience reports · 2025Review
- Therapeutic and Pharmaceutical Potential ofAntioxidants (Basel, Switzerland) · 2025Article
- Dietary anethole: a systematic review of its protective effects against metabolic syndrome.Journal of diabetes and metabolic disorders · 2024Article
- Mitochondrial carnitine palmitoyltransferase-II dysfunction: A possible novel mechanism for nonalcoholic fatty liver disease in hepatocarcinogenesis.World journal of gastroenterology · 2023Review
- Chemo-enzymatic synthesis and biological activity evaluation of propenylbenzene derivatives.Frontiers in microbiology · 2023Article
- Effect of Trans-Anethole on Gene Expression of Steroidogenic Enzymes in the Ovary of Polycystic Ovary Syndrome Model Rate:.Galen medical journal · 2022Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Non-alcoholic fatty liver disease is caused by excessive lipid accumulation in hepatocytes. Although trans-anethole (TAO) affects hypoglycemia and has anti-immune activity and anti-obesity effects, its role in non-alcoholic fatty liver disease remains unknown. This study aimed to evaluate the effects of TAO on cellular senescence, lipid metabolism, and reinforcement of microenvironments in HepG2 cells. To analyze the lipid metabolic activity of TAO, PCR analysis, flow-cytometry, and Oil Red O staining were performed, and mitochondrial membrane potential (MMP) and cellular senescence kits were used for assessing the suppression of cellular senescence. At 2000 μg/mL TAO, the cellular viability was approximately 99%, and cell senescence decreased dose-dependently. In the results for MMP, activity increased with concentration. The levels of lipolytic genes,
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.