ArticleJournal of clinical medicine2020
Daytime Neurophysiological Hyperarousal in Chronic Insomnia: A Study of qEEG.
Article in Journal of clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- Trial
- Decreased Control and Enhanced Reactivity: Dual Dysregulation Pattern of Cross-Frequency Coupling in Emotional Susceptibility of Non-Clinical Insomnia.CNS neuroscience & therapeutics · 2026Article
- Impaired sleep resilience underlies transient neural instability in insomnia disorder.iScience · 2026Article
- Sleep architecture differences and predictive markers of sleep perception impairment in depression.Scientific reports · 2026Article
- Neural Correlates of Restless Legs Syndrome (RLS) Based on Electroencephalogram (EEG)-A Mechanistic Review.International journal of molecular sciences · 2025Review
- Abnormal sensory processing cortex in insomnia disorder: a degree centrality study.Brain imaging and behavior · 2025Observational
- Neuropsychological Performance: How Mental Health Drives Attentional Function in University-Level Football Athletes.Sports (Basel, Switzerland) · 2025Article
- Heart rate variability during sleep onset in patients with insomnia with or without comorbid sleep apnea.Sleep medicine · 2024Article
- Sleep quality, circadian preferences, and mood among patients with acne vulgaris: a case-control study.Sleep & breathing = Schlaf & Atmung · 2023Article
- Gravitational Dose-Response Curves for Acute Cardiovascular Hemodynamics and Autonomic Responses in a Tilt Paradigm.Journal of the American Heart Association · 2022Article
- Temporal relations between peripheral and central arousals in good and poor sleepers.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Infra-low frequency neurofeedback and insomnia as a model of CNS dysregulation.Frontiers in human neuroscience · 2022Review
- Understanding insomnia as systemic disease.Yeungnam University journal of medicine · 2021Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe hyperarousal model demonstrates that instability of sleep-wake regulation leads to insomnia symptoms and various neurophysiological hyperarousal states. Previous studies have shown that hyperarousal states that appear in chronic insomnia patients are not limited to sleep at nighttime but are stable characteristics that extend into the daytime. However, this phenomenon is mainly measured at bedtime, so it hard to determine whether it is maintained throughout a 24 h cycle or if it just appears at bedtime.
methodsWe examined the resting state qEEG (quantitative electroencephalogram) and ECG (electrocardiogram) of chronic insomnia patients (
resultsAs compared with controls, participants with insomnia showed a clearly high beta band activity in eyes closed condition at all brain areas. They showed a low frequency band at the frontal area; high frequency bands at the central and parietal areas were found in eyes open condition. Significantly higher heart rates were also found in the chronic insomnia group.
conclusionThese findings suggest that chronic insomnia patients were in a state of neurophysiological hyperarousal during the middle of the day due to abnormal arousal regulation.
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Registered trials
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