Evidence map›Paper›PMID 33114361›Full record

ArticleMarine drugs2020

Disulfides from the Brown Alga

Maria G Daskalaki, Paraskevi Bafiti, Stefanos Kikionis, Maria Laskou, Vassilios Roussis, Efstathia Ioannou, Sotirios C Kampranis, Christos Tsatsanis

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Marine drugs, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Diet supplementation with the macroalgaeFrontiers in nutrition · 2026
    Article
  3. The Ocean's Pharmacy: Health Discoveries in Marine Algae.Molecules (Basel, Switzerland) · 2024
    Review
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Maria G DaskalakiLaboratory of Clinical Chemistry, School of Medicine, University of Crete, 70013 Heraklion, Greece.ORCID 0000-0002-4424-2779
Paraskevi BafitiLaboratory of Clinical Chemistry, School of Medicine, University of Crete, 70013 Heraklion, Greece.ORCID 0000-0002-7811-3764
Stefanos KikionisSection of Pharmacognosy and Chemistry of Natural Products, Department of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis Zographou, 15771 Athens, Greece.ORCID 0000-0002-0599-7490
Maria LaskouLaboratory of Clinical Chemistry, School of Medicine, University of Crete, 70013 Heraklion, Greece.
Vassilios RoussisSection of Pharmacognosy and Chemistry of Natural Products, Department of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis Zographou, 15771 Athens, Greece.ORCID 0000-0001-9856-4725
Efstathia IoannouSection of Pharmacognosy and Chemistry of Natural Products, Department of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis Zographou, 15771 Athens, Greece.ORCID 0000-0003-3103-4951
Sotirios C KampranisSection of Plant Biochemistry, Department of Plant and Environmental Sciences, University of Copenhagen, Thorvaldsensvej 40, 1871 Frederiksberg, Denmark.ORCID 0000-0001-6208-1684
Christos TsatsanisLaboratory of Clinical Chemistry, School of Medicine, University of Crete, 70013 Heraklion, Greece.ORCID 0000-0003-1214-4151
University of Crete · GRNational and Kapodistrian University of Athens · GRUniversity of Copenhagen · DK

Funding

European Union and Greek national funds through the Operational Program Competitiveness, Entrepreneurship and Innovation, under the call RESEARCH - CREATE - INNOVATE T1EDK-04048
6 · The paper itself

Abstract

Inflammation is part of the organism's response to deleterious stimuli, such as pathogens, damaged cells, or irritants. Macrophages orchestrate the inflammatory response obtaining different activation phenotypes broadly defined as M1 (pro-inflammatory) or M2 (homeostatic) phenotypes, which contribute to pathogen elimination or disease pathogenesis. The type and magnitude of the response of macrophages are shaped by endogenous and exogenous factors and can be affected by nutrients or therapeutic agents. Multiple studies have shown that natural products possess immunomodulatory properties and that marine algae contain products with such action. We have previously shown that disulfides isolated from

Indexed as

AnimalsAnti-Inflammatory AgentsDisulfidesExtracellular Signal-Regulated MAP KinasesGene Expression RegulationMacrophage ActivationMacrophagesMiceMitogen-Activated Protein Kinase KinasesPhaeophyceaeProto-Oncogene Proteins c-aktRAW 264.7 CellsAnti-Inflammatory AgentsDisulfidesExtracellular Signal-Regulated MAP KinasesMitogen-Activated Protein Kinase KinasesProto-Oncogene Proteins c-aktAKTDictyopteris membranaceadisulfidesERK1/2IL-6inflammationiNOSmacrophagesTNFα

Identifiers

PMID33114361
PMCPMC7690855
OpenAlexW3094248030

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.