Evidence map›Paper›PMID 33114343›Full record

ReviewInternational journal of environmental research and public health2020

New Insights into Mechanisms of Endocrine-Disrupting Chemicals in Thyroid Diseases: The Epigenetic Way.

Letizia Pitto, Francesca Gorini, Fabrizio Bianchi, Elena Guzzolino

Open access · goldAbstract readReview
In one paragraph

Review in International journal of environmental research and public health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Letizia PittoInstitute of Clinical Physiology, National Research Council, 56124 Pisa, Italy.ORCID 0000-0002-8660-9516
Francesca GoriniInstitute of Clinical Physiology, National Research Council, 56124 Pisa, Italy.ORCID 0000-0002-4619-6227
Fabrizio BianchiInstitute of Clinical Physiology, National Research Council, 56124 Pisa, Italy.ORCID 0000-0002-3459-9301
Elena GuzzolinoInstitute of Clinical Physiology, National Research Council, 56124 Pisa, Italy.
Istituto di Fisiologia Clinica · ITUniversity of Milan · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In recent years, the presence in the environment of chemical compounds with thyroid-disrupting effects is progressively increased. This phenomenon has risen concern for human health as the preservation of thyroid system homeostasis is essential for fetal development and for maintaining psychological and physiological wellbeing. An increasing number of studies explored the role of different classes of toxicants in the occurrence and severity of thyroid diseases, but large epidemiological studies are limited and only a few animal or in vitro studies have attempted to identify the mechanisms of chemical action. Recently, epigenetic changes such as alteration of methylation status or modification of non-coding RNAs have been suggested as correlated to possible deleterious effects leading to different thyroid disorders in susceptible individuals. This review aims to analyze the epigenetic alterations putatively induced by chemical exposures and involved in the onset of frequent thyroid diseases such as thyroid cancer, autoimmune thyroiditis and disruption of fetal thyroid homeostasis.

Indexed as

Endocrine DisruptorsAnimalsEpigenesis, GeneticEpigenomicsHazardous SubstancesHumansEndocrine DisruptorsHazardous Substancesendocrine disrupting compoundsenvironmental pollutionepigeneticsexposurethyroid

Identifiers

PMID33114343
PMCPMC7662297
OpenAlexW3093738275

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.