Evidence map›Paper›PMID 33114130›Full record

ArticleNutrients2020

Bilberry Anthocyanins Ameliorate NAFLD by Improving Dyslipidemia and Gut Microbiome Dysbiosis.

Hironobu Nakano, Shusong Wu, Kozue Sakao, Taichi Hara, Jianhua He, Santos Garcia, Kalidas Shetty, De-Xing Hou

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it, 67 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Nutrients · 2024
    Review
  10. Acupuncture influences multiple diseases by regulating gut microbiota.Frontiers in cellular and infection microbiology · 2024
    Review
  11. Article
  12. Review
  13. Effects of Amazake Produced with DifferentFoods (Basel, Switzerland) · 2023
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 4 countries.

Hironobu NakanoGraduate School of Agriculture, Kagoshima University, Kagoshima 890-0065, Japan.
Shusong WuCollege of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China.
Kozue SakaoGraduate School of Agriculture, Kagoshima University, Kagoshima 890-0065, Japan.
Taichi HaraFaculty of Human Sciences, Waseda University, 2-579-15 Mikajima, Tokorozawa, Saitama 359-1192, Japan.ORCID 0000-0002-4722-6336
Jianhua HeCollege of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China.ORCID 0000-0002-9289-4405
Santos GarciaFac. C. Biologicas, Universidad Autonoma de Nuevo Leon, San Nicolas 66451, Mexico.ORCID 0000-0001-7405-5504
Kalidas ShettyDepartment of Plant Science, North Dakota State University, Fargo, ND 58105, USA.
De-Xing HouGraduate School of Agriculture, Kagoshima University, Kagoshima 890-0065, Japan.ORCID 0000-0002-0449-8331
Kagoshima University · JPHunan Agricultural University · CNNorth Dakota State University · USUniversidad Autónoma de Nuevo León · MXWaseda University · JP

Funding

Grant-in-Aid for scientific research of the Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan 20K05928Scholar Research of Kagoshima University Fund 70030117
6 · The paper itself

Abstract

Non-alcoholic fatty liver disease (NAFLD) is a manifestation of metabolic syndrome closely linked to dyslipidemia and gut microbiome dysbiosis. Bilberry anthocyanins (BA) have been reported to have preventive effects against metabolic syndrome. This study aimed to investigate the protective effects and mechanisms of BA in a Western diet (WD)-induced mouse model. The results revealed that supplementation with BA attenuated the serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), low-density lipoprotein cholesterol (LDL-c), fat content in liver, 2-thiobarbituric acid reactive substances (TBARS) and α-smooth muscle actin (α-SMA) caused by WD. Furthermore, gut microbiota characterized by 16S rRNA sequencing revealed that BA reduced remarkably the ratio of Firmicutes/Bacteroidetes (F/B) and modified gut microbiome. In particular, BA increased the relative abundance of g_

Indexed as

Alanine TransaminaseAnimalsAnthocyaninsAspartate AminotransferasesCholesterol, LDLDietary SupplementsDiet, WesternDisease Models, AnimalDysbiosisDyslipidemiasGastrointestinal MicrobiomeLiverMetabolic SyndromeMiceNon-alcoholic Fatty Liver DiseaseRNA, Ribosomal, 16SAlanine TransaminaseAnthocyaninsAspartate AminotransferasesCholesterol, LDLRNA, Ribosomal, 16Santhocyaninsbilberrydyslipidemiagut microbiomeNAFLD

Identifiers

PMID33114130
PMCPMC7690841
OpenAlexW3093513867

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.