Evidence map›Paper›PMID 33114123›Full record

ArticlePathogens (Basel, Switzerland)2020

Identifying Candidate Genetic Markers of CDV Cross-Species Pathogenicity in African Lions.

Julie K Weckworth, Brian W Davis, Melody E Roelke-Parker, Rebecca P Wilkes, Craig Packer, Ernest Eblate, Michael K Schwartz, L Scott Mills

Open access · goldAbstract read
In one paragraph

Article in Pathogens (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 7 institutions in 2 countries.

Julie K WeckworthWildlife Biology Program, Department of Ecosystem and Conservation Sciences, W. A. Franke College of Forestry and Conservation, University of Montana, Missoula, MT 59812, USA.
Brian W DavisDepartment of Veterinary Integrative Biosciences, Texas A&M University College of Veterinary Medicine, College Station, TX 77843, USA.
Melody E Roelke-ParkerLeidos Biomedical Research, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.
Rebecca P WilkesDepartment of Comparative Pathobiology, Animal Disease Diagnostic Laboratory, Purdue University College of Veterinary Medicine, West Lafayette, IN 47907, USA.
Craig PackerDepartment of Ecology, Evolution and Behavior, University of Minnesota, St. Paul, MN 55108, USA.
Ernest EblateTanzania Wildlife Research Institute, Arusha P.O. Box 661, Tanzania.
Michael K SchwartzWildlife Biology Program, Department of Ecosystem and Conservation Sciences, W. A. Franke College of Forestry and Conservation, University of Montana, Missoula, MT 59812, USA.
L Scott MillsFisheries, Wildlife, and Conservation Biology Program, Department of Forestry and Environmental Resources, North Carolina State University, Raleigh, NC 27695, USA.
United States Department of Agriculture · USLeidos (United States) · USNorth Carolina State University · USPurdue University West Lafayette · USTanzania Wildlife Research Institute · TZTexas A&M University · USUniversity of Minnesota · US

Funding

Morris Animal Foundation D14ZO-013National Science Foundation #DGE-0504628National Science Foundation #DGE-0809127
6 · The paper itself

Abstract

Canine distemper virus (CDV) is a multi-host pathogen with variable clinical outcomes of infection across and within species. We used whole-genome sequencing (WGS) to search for viral markers correlated with clinical distemper in African lions. To identify candidate markers, we first documented single-nucleotide polymorphisms (SNPs) differentiating CDV strains associated with different clinical outcomes in lions in East Africa. We then conducted evolutionary analyses on WGS from all global CDV lineages to identify loci subject to selection. SNPs that both differentiated East African strains and were under selection were mapped to a phylogenetic tree representing global CDV diversity to assess if candidate markers correlated with documented outbreaks of clinical distemper in lions (

Indexed as

African lioncanine distemper viruscross-species pathogenicityevolutionary geneticsmulti-host pathogenspilloverviral genomics

Identifiers

PMID33114123
PMCPMC7690837
OpenAlexW3093702883

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.