ReviewBrain sciences2020
Semantic Processing in Healthy Aging and Alzheimer's Disease: A Systematic Review of the N400 Differences.
Review in Brain sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- The neurophysiology of healthy and pathological aging: a comprehensive systematic review.Brain structure & function · 2025Pooled it
- Development of the N400 for Word Learning in the First 2 Years of Life: A Systematic Review.Frontiers in psychology · 2021Pooled it
- Conceptual but not perceptual encoding leads to age differences in priming.Memory & cognition · 2026Article
- FREQ-NESS Reveals Age-Related Differences in Frequency-Resolved Brain Networks During Auditory Recognition and Resting State.Annals of the New York Academy of Sciences · 2026Article
- Multimodal non-invasive approaches for early Alzheimer's disease detection: a review of neuroelectrophysiological and neuroimaging techniques.Frontiers in psychiatry · 2026Review
- Article
- Dataset of 37-subject EEG recordings using a low-cost mobile EEG headset during a semantic relatedness judgment task.Data in brief · 2025Article
- Biomarker and neuropsychological correlates of the N400 event-related potential in Alzheimer's disease.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2025Article
- Beyond the left cerebral hemisphere: bilateral language lateralization in healthy aging and its clinical implications.Frontiers in aging neuroscience · 2025Article
- Applications of event-related potentials in Alzheimer's disease: a systematic review and analysis.Frontiers in aging neuroscience · 2025Review
- Complex span measures of working memory do not mediate the effects of age on the P3 and N400 ERPs.Aging brain · 2025Article
- Time course of indirect reply comprehension in the young and older adults: an event-related potential study.Frontiers in psychology · 2025Article
- Exploring the Utility of the Muse Headset for Capturing the N400: Dependability and Single-Trial Analysis.Sensors (Basel, Switzerland) · 2024Article
- Evaluating frontoparietal network topography for diagnostic markers of Alzheimer's disease.Scientific reports · 2024Article
- Disintegration at the Syntax-Semantics Interface in Prodromal Alzheimer's Disease: New Evidence from Complex Sentence Anaphora in Amnestic Mild Cognitive Impairment (aMCI).Journal of neurolinguistics · 2024Article
- Brain vital signs as a quantitative measure of cognition: Methodological implementation in a care home environment.Heliyon · 2024Article
- The role of semantic assessment in the differential diagnosis between late-life depression and Alzheimer's disease or amnestic mild cognitive impairment: systematic review and meta-analysis.European journal of ageing · 2023Review
- The neurophysiology of the intervention strategies of Awareness Training Program on emotion regulation.Frontiers in psychology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Semantic deficits are common in individuals with Alzheimer's disease (AD). These deficits notably impact the ability to understand words. In healthy aging, semantic knowledge increases but semantic processing (i.e., the ability to use this knowledge) may be impaired. This systematic review aimed to investigate semantic processing in healthy aging and AD through behavioral responses and the N400 brain event-related potential. The results of the quantitative and qualitative analyses suggested an overall decrease in accuracy and increase in response times in healthy elderly as compared to young adults, as well as in individuals with AD as compared to age-matched controls. The influence of semantic association, as measured by N400 effect amplitudes, appears smaller in healthy aging and even more so in AD patients. Thus, semantic processing differences may occur in both healthy and pathological aging. The establishment of norms of healthy aging for these outcomes that vary between normal and pathological aging could eventually help early detection of AD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.