Evidence map›Paper›PMID 33114008›Full record

ArticleInternational journal of molecular sciences2020

Impact of a Model Used to Simulate Chronic Socio-Environmental Stressors Encountered during Spaceflight on Murine Intestinal Microbiota.

Corentine Alauzet, Lisiane Cunat, Maxime Wack, Laurence Lanfumey, Christine Legrand-Frossi, Alain Lozniewski, Nelly Agrinier, Catherine Cailliez-Grimal, Jean-Pol Frippiat

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Polysaccharides fromHeliyon · 2024
    Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Surface Properties ofMicroorganisms · 2021
    Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Corentine AlauzetStress Immunity Pathogens unit (SIMPA), EA 7300, Université de Lorraine, F-54000 Nancy, France.ORCID 0000-0001-7953-4870
Lisiane CunatStress Immunity Pathogens unit (SIMPA), EA 7300, Université de Lorraine, F-54000 Nancy, France.
Maxime WackDépartement d'Informatique Médicale, Biostatistiques et Santé Publique, Hôpital Européen Georges Pompidou, Assistance Publique-Hôpitaux de Paris, 75015 Paris, France.ORCID 0000-0002-4989-5533
Laurence LanfumeyInstitute of Psychiatry and Neuroscience of Paris (IPNP), INSERM U1266, Université de Paris, F-75014 Paris, France.ORCID 0000-0002-4725-2737
Christine Legrand-FrossiStress Immunity Pathogens unit (SIMPA), EA 7300, Université de Lorraine, F-54000 Nancy, France.
Alain LozniewskiStress Immunity Pathogens unit (SIMPA), EA 7300, Université de Lorraine, F-54000 Nancy, France.
Nelly AgrinierCHRU-Nancy, INSERM, Université de Lorraine, CIC, Epidémiologie Clinique, F-54000 Nancy, France.
Catherine Cailliez-GrimalStress Immunity Pathogens unit (SIMPA), EA 7300, Université de Lorraine, F-54000 Nancy, France.
Jean-Pol FrippiatStress Immunity Pathogens unit (SIMPA), EA 7300, Université de Lorraine, F-54000 Nancy, France.ORCID 0000-0002-4027-6269
Stress, immunité, pathogènesInserm · FRCentre Hospitalier Régional et Universitaire de Nancy · FR

Funding

Centre National d'Etudes Spatiales DAR 4800000894, 4800000950 and 4800001008Université de Lorraine CPER
6 · The paper itself

Abstract

During deep-space travels, crewmembers face various physical and psychosocial stressors that could alter gut microbiota composition. Since it is well known that intestinal dysbiosis is involved in the onset or exacerbation of several disorders, the aim of this study was to evaluate changes in intestinal microbiota in a murine model used to mimic chronic psychosocial stressors encountered during a long-term space mission. We demonstrate that 3 weeks of exposure to this model (called CUMS for Chronic Unpredictable Mild Stress) induce significant change in intracaecal β-diversity characterized by an important increase of the

Indexed as

AnimalsBacillotaBacteriaBacteroidetesCase-Control StudiesDisease Models, AnimalDysbiosisGastrointestinal MicrobiomeHumansMaleMicePhylogenySequence Analysis, DNASpace FlightStress, PsychologicalBarnesiellachronic unpredictable mild stressgut microbiotaspaceflight

Identifiers

PMID33114008
PMCPMC7672645
OpenAlexW3094495520

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.