Evidence map›Paper›PMID 33113879›Full record

ArticleInternational journal of molecular sciences2020

Transcriptomic Analysis of Age-Associated Periventricular Lesions Reveals Dysregulation of the Immune Response.

Motaz M Fadul, Paul R Heath, Johnathan Cooper-Knock, Julian M Kurz, Hayder A Al-Azzawi, Zarki Ali, Taylor Smith, Fiona E Matthews, Carol Brayne, Stephen B Wharton and 1 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Motaz M FadulSheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK.ORCID 0000-0002-2208-9988
Paul R HeathSheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK.ORCID 0000-0002-8385-1438
Johnathan Cooper-KnockSheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK.ORCID 0000-0002-0873-8689
Julian M KurzSheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK.ORCID 0000-0002-0196-4608
Hayder A Al-AzzawiSheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK.
Zarki AliSheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK.
Taylor SmithSheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK.
Fiona E MatthewsInstitute of Public Health, University of Cambridge, Cambridge CB2 0SR, UK.
Carol BrayneInstitute of Public Health, University of Cambridge, Cambridge CB2 0SR, UK.
Stephen B WhartonSheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK.
Julie E SimpsonSheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK.ORCID 0000-0002-3753-4271
University of Sheffield · GBUniversity of Cambridge · GB

Funding

King Abdulaziz University -Medical Research Council G0601022Medical Research Council G9901400
6 · The paper itself

Abstract

White matter lesions (WML) are a common feature of the ageing brain associated with cognitive impairment. The gene expression profiles of periventricular lesions (PVL,

Indexed as

AgedAged, 80 and overAge FactorsAgingCase-Control StudiesCerebral VentriclesCohort StudiesFemaleGene Expression ProfilingHumansImmunityMaleMicrogliaSignal TransductionTranscriptomeWhite Matterimmune responsenanostringperiventricular lesionstranscriptomic profiling

Identifiers

PMID33113879
PMCPMC7663268
OpenAlexW3094043103

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.