Evidence map›Paper›PMID 33113592›Full record

ReviewAnnals of the New York Academy of Sciences2021

Presence of Ebola virus in breast milk and risk of mother-to-child transmission: synthesis of evidence.

Melisa Medina-Rivera, Elizabeth Centeno-Tablante, Julia L Finkelstein, Pura Rayco-Solon, Juan Pablo Peña-Rosas, Maria N Garcia-Casal, Lisa Rogers, Pratiwi Ridwan, Sabrina Sales Martinez, Joyce Andrade and 5 more

Open access · hybridAbstract readReview
In one paragraph

Review in Annals of the New York Academy of Sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.4field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Viruses and Human Milk: Transmission or Protection?Advances in nutrition (Bethesda, Md.) · 2023
    Review
  6. Review
  7. Review
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 3 countries.

Melisa Medina-RiveraDivision of Nutritional Sciences, Cornell University, Ithaca, New York.ORCID 0000-0001-7074-5663
Elizabeth Centeno-TablanteDivision of Nutritional Sciences, Cornell University, Ithaca, New York.ORCID 0000-0001-6480-8779
Julia L FinkelsteinDivision of Nutritional Sciences, Cornell University, Ithaca, New York.ORCID 0000-0001-9512-5559
Pura Rayco-SolonDepartment of Maternal, Newborn, Child and Adolescent Health and Ageing, World Health Organization, Geneva, Switzerland.ORCID 0000-0002-6548-1269
Juan Pablo Peña-RosasDepartment of Nutrition and Food Safety, World Health Organization, Geneva, Switzerland.ORCID 0000-0002-6737-9831
Maria N Garcia-CasalDepartment of Nutrition and Food Safety, World Health Organization, Geneva, Switzerland.
Lisa RogersDepartment of Nutrition and Food Safety, World Health Organization, Geneva, Switzerland.
Pratiwi RidwanDivision of Nutritional Sciences, Cornell University, Ithaca, New York.ORCID 0000-0002-8694-4920
Sabrina Sales MartinezDepartment of Dietetics and Nutrition, Robert Stempel College of Public Health and Social Work, Florida International University, Miami, Florida.
Joyce AndradeHospital de Niños Roberto Gilbert Elizalde, Guayaquil, Ecuador.
Alexander J LaydenDepartment of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania.
Juan ChangHospital de Niños Roberto Gilbert Elizalde, Guayaquil, Ecuador.
Mildred P ZambranoHospital de Niños Roberto Gilbert Elizalde, Guayaquil, Ecuador.
Kate Ghezzi-KopelAlbert R. Mann Library, Cornell University, Ithaca, New York.ORCID 0000-0002-8777-402X
Saurabh MehtaDivision of Nutritional Sciences, Cornell University, Ithaca, New York.ORCID 0000-0003-3788-0665
Cornell University · USWorld Health Organization · CHFlorida International University · USUniversity of Pittsburgh · US

Funding

J. NRSA Training CoreTL1TR002386 · NCATS · WEILL MEDICAL COLL OF CORNELL UNIV · PI Genevieve Giny Fouda Amou ou · 2017 to 2026
$5.8M
NCATS NIH HHS TL1 TR002386World Health Organization 001
6 · The paper itself

Abstract

To help inform global guidelines on infant feeding, this systematic review synthesizes evidence related to the presence of the Ebola virus (EBOV) in breast milk and its potential risk of viral transmission to the infant when breastfeeding. We relied on a comprehensive search strategy to identify studies including women with suspected, probable, or confirmed EBOV infection, intending to breastfeed or give breast milk to an infant. Our search identified 10,454 records, and after deduplication and screening, we assessed 148 full texts. We included eight studies reporting on 10 breastfeeding mothers and their children (one mother with twins), who provided breast milk samples for assessment. EBOV was detected via RT-PCR or viral culture in seven out of ten breast milk samples. Four out of the five-breastfed infants with EBOV-positive breast milk were found positive for EBOV infection, and all of these EBOV-positive infants died. Since previous reports have detected EBOV in tears, saliva, sweat, and contaminated surfaces, with the current evidence, it is not possible to conclude with certainty that breast milk was the main route of EBOV transmission.

Indexed as

Breast FeedingCross-Sectional StudiesEbolavirusFemaleHemorrhagic Fever, EbolaHumansInfantInfant, NewbornInfectious Disease Transmission, VerticalMilk, HumanRandomized Controlled Trials as TopicRisk Factorsbreastfeedingbreast milkEbola virusmother-to-child transmissionperinatal transmissionvertical transmission

Identifiers

PMID33113592
PMCPMC8048832
OpenAlexW3095642433

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.