ReviewBiosensors & bioelectronics2021
Multiplexed cytokine detection using electrochemical point-of-care sensing device towards rapid sepsis endotyping.
Review in Biosensors & bioelectronics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 87 citations in OpenAlex.
- Biologic Mechanisms Underlying the Heterogeneous Response to Tight Glycemic Control among Differentially Inflamed Patients in the HALF-PINT Trial.American journal of respiratory and critical care medicine · 2025Trial
- The molecular ICU: a primer on omics, informatics and the future of precision critical care.Critical care (London, England) · 2026Review
- Recent advances in the biosensing platforms for sepsis diagnosis.RSC advances · 2026Review
- Review
- Identification of immune status subtypes and prognostic analysis of septic patients based on Th1/Th2 cytokine assays.Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2026Article
- Electrochemical Biosensor for Rapid Detection of Acute Rejection in Kidney Transplants.Advanced healthcare materials · 2026Article
- Stratified assessment of platelets in sepsis: from dynamic counts to functional phenotypes.Frontiers in immunology · 2026Review
- Higher admission IL-6 levels are associated with higher platelet levels at discharge in sepsis patients.Annals of medicine and surgery (2012) · 2026Article
- Transforming cytokine diagnostics: AI, multiplexing, and point-of-care biosensing technologies.Mikrochimica acta · 2025Review
- From reactive to proactive: Continuous protein monitoring for preventive health care.Science (New York, N.Y.) · 2025Review
- Label-Free Electrochemical Interleukin-6 Sensor Exploiting rGO-TiACS applied materials & interfaces · 2025Article
- Development of Cortisol Sensors with Interdigitated Electrode Platforms Based on Barium Titanate Nanoparticles.Sensors (Basel, Switzerland) · 2025Article
- An Attomolar-Level Optical Device for Monitoring Receptor-Analyte Interactions Without Functionalization Steps: A Case Study of Cytokine Detection.Sensors (Basel, Switzerland) · 2025Article
- Protein recognition methods for diagnostics and therapy.BBA advances · 2025Review
- Electrochemical Profiling of vWFA2 for Systemic Inflammatory State Detection.ACS measurement science au · 2024Article
- Synthesis and characterization of core-shell magnetic molecularly imprinted polymer nanocomposites for the detection of interleukin-6.Analytical and bioanalytical chemistry · 2024Article
- Early serum biomarkers to characterise different phenotypes of primary graft dysfunction after lung transplantation: a systematic scoping review.ERJ open research · 2024Article
- Visceral Leishmaniasis in a Twin Pregnancy: A Case Report and Review of the Literature.Journal of clinical medicine · 2024Review
- Prognostic value of inflammatory cytokine detection for sepsis patients in ICU: a meta-analysis.American journal of translational research · 2024Review
- Electrochemical Label-free Methods for Ultrasensitive Multiplex Protein Profiling of Infectious Diseases.Current medicinal chemistry · 2024Review
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The implementation of endotype-driven effective intervention strategies is now considered as an essential component for sepsis management. Rapid screening and frequent monitoring of immune responses are critical for evidence-based informed decisions in the early hours of patient arrival. Current technologies focus on pathogen identification that lack rapid testing of the patient immune response, impeding clinicians from providing appropriate sepsis treatment. Herein, we demonstrate a first-of-its-kind novel point-of-care device that uses a unique approach by directly monitoring a panel of five cytokine biomarkers (IL-6, IL-8, IL-10, TRAIL & IP-10), that is attributed as a sign of the body's host immune response to sepsis. The developed point-of-care device encompasses a disposable sensor cartridge attached to an electrochemical reader. High sensitivity is achieved owing to the unique sensor design with an array of nanofilm semiconducting/metal electrode interface, functionalized with specific capture probes to measure target biomarkers simultaneously using non-faradaic electrochemical impedance spectroscopy. The sensor has a detection limit of ~1 pg/mL and provides results in less than five minutes from a single drop of undiluted plasma sample. Furthermore, the sensor demonstrates an excellent correlation (Pearson's r > 0.90) with the reference method for a total n = 40 clinical samples, and the sensor's performance is ~30 times faster compared to the standard reference technique. We have demonstrated the sensor's effectiveness to enhance diagnosis with a mechanistic biomarker-guided approach that can help disease endotypying for effective clinical management of sepsis at the patient bedside.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.