ArticleCell reports2020
Endocannabinoid Receptor-1 and Sympathetic Nervous System Mediate the Beneficial Metabolic Effects of Gastric Bypass.
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Article in Cell reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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30citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
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Who cites it
30 citing papers in PubMed, 42 citations in OpenAlex.
- RYGB induces vagal sensory neuropathy characterized by altered Glp1r expression and enhanced exendin-4 responsiveness in male mice.American journal of physiology. Endocrinology and metabolism · 2026Article
- Diet-dependent modulation of energy balance by CB1 signaling in peripheral sensory neurons.iScience · 2025Article
- Early Impact of Bariatric Surgery on Brain Functionality.Journal of metabolic and bariatric surgery · 2025Review
- The role of the gut-brain axis in bariatric surgery.Current opinion in neurobiology · 2025Review
- A Standardized Method for Vertical Sleeve Gastrectomy Bariatric Surgery Investigations in Cancer.Frontiers in microbiomes · 2025Article
- Neural Circuits Underlying Reciprocal Cardiometabolic Crosstalk: 2023 Arthur C. Corcoran Memorial Lecture.Hypertension (Dallas, Tex. : 1979) · 2024Article
- Influence of Bariatric Surgery on Gut Microbiota Composition and Its Implication on Brain and Peripheral Targets.Nutrients · 2024Review
- Spinal afferent neurons: emerging regulators of energy balance and metabolism.Frontiers in molecular neuroscience · 2024Review
- Early-life sodium deprivation programs long-term changes in ingestive behaviors and energy expenditure in C57BL/6J mice.American journal of physiology. Regulatory, integrative and comparative physiology · 2023Article
- Hypoabsorptive surgeries cause limb-dependent changes in the gut endocannabinoidome and microbiome in association with beneficial metabolic effects.International journal of obesity (2005) · 2023Article
- Gastric bypass alters diurnal feeding behavior and reprograms the hepatic clock to regulate endogenous glucose flux.JCI insight · 2023Article
- Remodeling of Adipose Tissues by Fatty Acids: Mechanistic Update on Browning and Thermogenesis by n-3 Polyunsaturated Fatty Acids.Pharmaceutical research · 2023Review
- Peripheral and central macrophages in obesity.Frontiers in endocrinology · 2023Review
- Brain-to-BAT - and Back?: Crosstalk between the Central Nervous System and Thermogenic Adipose Tissue in Development and Therapy of Obesity.Brain sciences · 2022Review
- The role of obesity and bariatric surgery-induced weight loss in breast cancer.Cancer metastasis reviews · 2022Review
- Targeting tumor innervation: premises, promises, and challenges.Cell death discovery · 2022Review
- Neurohormonal Changes in the Gut-Brain Axis and Underlying Neuroendocrine Mechanisms following Bariatric Surgery.International journal of molecular sciences · 2022Review
- The Endocannabinoid System, an Underexploited and Promising Niche for the Pharmacological Treatment of Obesity and Metabolic Diseases.Nutrients · 2022Article
- Mechanisms of Weight Loss After Obesity Surgery.Endocrine reviews · 2022Review
- Toll-like receptor 4 and myeloid differentiation factor 88 are required for gastric bypass-induced metabolic effects.Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery · 2021Article
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Authors and funding
28 authors at 10 institutions in 3 countries.
Yuanchao YeDepartment of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA.
Marwa Abu El HaijaDepartment of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, Stanford University School of Medicine, Palo Alto, CA 94304, USA.
Donald A MorganDepartment of Neuroscience and Pharmacology, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA.
Deng GuoDepartment of Neuroscience and Pharmacology, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA.
Yang SongCollege of Pharmacy, China Medical University, 77 Puhe Rd., Liaoning 110122, P.R. China.
Aaron FrankThe Biomedical Research Department, Diabetes and Obesity Research Division, Cedars Sinai Medical Center, Beverly Hills, CA 90048, USA.
Liping TianDepartment of Clinical Pharmacy, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu 211198, P.R. China.
Ruth A RiedlDepartment of Neuroscience and Pharmacology, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA.
Colin M L BurnettDepartment of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA; Department of Neuroscience and Pharmacology, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA.
Zhan GaoDepartment of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA.
Zhiyong ZhuDepartment of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA.
Shailesh K ShahiDepartment of Pathology, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA.
Kasra ZareiMedical Scientist Training Program, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA.
Anne CouvelardINSERM U1149, Centre de Recherche sur l'Inflammation, Université de Paris, Paris 75018, France; Department of Pathology, Bichat Hospital, AP-HP, Paris 75018, France.
Nicolas PotéINSERM U1149, Centre de Recherche sur l'Inflammation, Université de Paris, Paris 75018, France; Department of Pathology, Bichat Hospital, AP-HP, Paris 75018, France.
Lara Ribeiro-ParentiINSERM U1149, Centre de Recherche sur l'Inflammation, Université de Paris, Paris 75018, France; Department of General and Digestive Surgery, Bichat Hospital, AP-HP, Paris 75018, France.
André BadoINSERM U1149, Centre de Recherche sur l'Inflammation, Université de Paris, Paris 75018, France.
Lama NoureddineDepartment of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA.
Andrew BellizziDepartment of Pathology, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA.
Paul KievitDivision of Diabetes, Obesity and Metabolism, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006, USA.
Ashutosh K MangalamDepartment of Pathology, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA; Interdisciplinary Graduate Program in Immunology and Molecular Medicine, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA.
Leonid V ZingmanDepartment of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA; Fraternal Orders of Eagles Diabetes Research Center, Iowa City, IA 52242, USA; Veterans Affairs Health Care System, Iowa City, IA 52242, USA; Obesity Research & Education Initiative, University of Iowa, Iowa City, IA 52242, USA.
Maude Le GallINSERM U1149, Centre de Recherche sur l'Inflammation, Université de Paris, Paris 75018, France.
Justin L GrobeDepartments of Physiology and Biomedical Engineering, Medical College of Wisconsin, Milwaukee, MI 53226, USA.
Lee M KaplanDepartment of Medicine, Harvard Medical School, Boston, MA 02115, USA; Obesity, Metabolism, and Nutrition Institute, Massachusetts General Hospital, Boston, MA 02114, USA.
Deborah CleggCollege of Nursing and Health Professions, Drexel University, 1601 Cherry Street, Philadelphia, PA 19102, USA.
Kamal RahmouniDepartment of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA; Department of Neuroscience and Pharmacology, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA; Medical Scientist Training Program, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA; Fraternal Orders of Eagles Diabetes Research Center, Iowa City, IA 52242, USA; Veterans Affairs Health Care System, Iowa City, IA 52242, USA; Obesity Research & Education Initiative, University of Iowa, Iowa City, IA 52242, USA.
Mohamad MokademDepartment of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA; Department of Neuroscience and Pharmacology, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA; Fraternal Orders of Eagles Diabetes Research Center, Iowa City, IA 52242, USA; Veterans Affairs Health Care System, Iowa City, IA 52242, USA; Obesity Research & Education Initiative, University of Iowa, Iowa City, IA 52242, USA. Electronic address: mohamad-mokadem@uiowa.edu.
University of Iowa · USInserm · FRCedars-Sinai Medical Center · USChina Medical University · CNChina Pharmaceutical University · CNDrexel University · USHarvard University · USMedical College of Wisconsin · USOregon National Primate Research Center · USStanford University · US
Funding
Clinical and Translational Science AwardUL1TR001436 · NCATS · MEDICAL COLLEGE OF WISCONSIN · PI FREED, JULIE K · 2015 to 2025
$47.5MPulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI Jong Sung Kim · 1990 to 2026
$40.5MRole of the brain Renin-Angiotensin Sys. in Cardiovas and Metabolic RegulationP01HL084207 · NHLBI · UNIVERSITY OF IOWA · PI SIGMUND, CURT DANIEL · 2007 to 2022
$30.2MInteraction between leptin and angiotensin in the pathogenesis of obesity-hypertensionR01HL134850 · NHLBI · UNIVERSITY OF IOWA · PI Justin L Grobe · 2017 to 2026
$4.4MSHORT-TERM TRAINING: STUDENTS IN HEALTH PROF. SCHOOLST35HL007485 · NHLBI · UNIVERSITY OF IOWA · PI ROGHAIR, ROBERT D · 1985 to 2019
$4.3MNeuroendocrine Response to Gastric Bypass in Nonhuman PrimatesRC4DK090956 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI ELMQUIST, JOEL K., GROVE, KEVIN L · 2010 to 2010
$3.8MSkeletal muscle KATP channels determine bodily energy balanceR01DK092412 · NIDDK · UNIVERSITY OF IOWA · PI ZINGMAN, LEONID · 2012 to 2016
$1.6MRequest for Funds to Purchase a Replacement Laser Scanning Confocal MicroscopeS10RR025439 · NCRR · UNIVERSITY OF IOWA · PI ZABNER, JOSEPH · 2009 to 2009
$500kSkeletal muscle ATP-sensitive potassium channels determine bodily energy balanceI01BX000718 · VA · IOWA CITY VA MEDICAL CENTER · PI ZINGMAN, LEONID · 2011 to 2015
–Regulation of glucose homeostasis via the molecular clock machinery and the hepatic vagus nerve after Roux-en-Y gastric bypassI01BX004774 · VA · IOWA CITY VA MEDICAL CENTER · PI Mohamad Mokadem · 2020 to 2026
–Neuronal Mechanisms of Obesity-Induced HypertensionI01BX004249 · VA · IOWA CITY VA MEDICAL CENTER · PI KAMAL RAHMOUNI · 2019 to 2026
–BLRD VA I01 BX000718BLRD VA I01 BX004249BLRD VA I01 BX004774NCATS NIH HHS UL1 TR001436NCRR NIH HHS S10 RR025439NHLBI NIH HHS P01 HL084207NHLBI NIH HHS R01 HL134850NHLBI NIH HHS T35 HL007485NIDDK NIH HHS R01 DK092412NIDDK NIH HHS RC4 DK090956NIEHS NIH HHS P30 ES005605
Abstract
The exact mechanisms underlying the metabolic effects of bariatric surgery remain unclear. Here, we demonstrate, using a combination of direct and indirect calorimetry, an increase in total resting metabolic rate (RMR) and specifically anaerobic RMR after Roux-en-Y gastric bypass (RYGB), but not sleeve gastrectomy (SG). We also show an RYGB-specific increase in splanchnic sympathetic nerve activity and "browning" of visceral mesenteric fat. Consequently, selective splanchnic denervation abolishes all beneficial metabolic outcomes of gastric bypass that involve changes in the endocannabinoid signaling within the small intestine. Furthermore, we demonstrate that administration of rimonabant, an endocannabinoid receptor-1 (CB1) inverse agonist, to obese mice mimics RYGB-specific effects on energy balance and splanchnic nerve activity. On the other hand, arachidonoylethanolamide (AEA), a CB1 agonist, attenuates the weight loss and metabolic signature of this procedure. These findings identify CB1 as a key player in energy regulation post-RYGB via a pathway involving the sympathetic nervous system.
Indexed as
AnimalsEndocannabinoidsFemaleGastric BypassHumansMaleMiceSympathetic Nervous SystemEndocannabinoidsendocannabinoid receptor-1energy expendituregastric bypassobesityresting metabolic ratesleeve gastrectomysympathetic nervous systemthermogenesis
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