ArticleCell2020
CNS-Native Myeloid Cells Drive Immune Suppression in the Brain Metastatic Niche through Cxcl10.
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Article in Cell, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 122 papers.
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122citing papers in PubMed
7.2field-weighted citation impact, top 2% of its field
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Who cites it
122 citing papers in PubMed, 145 citations in OpenAlex.
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- Therapeutic mechanisms of umbilical cord mesenchymal stem cell-derived exosomes in ischemic stroke: A transcriptomic and metabolomic study.Neural regeneration research · 2026Article
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- Multi-omics analysis and experimental validation reveal the IRF7-CXCL10 axis as a master regulator of microglial PCD in ischemic stroke.Cell biology and toxicology · 2026Article
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- Natural panax notoginseng-derived nanovesicles trigger multiple cell death mechanisms and reprogram chemokine signaling to impede oral squamous cell carcinoma progression.Journal of nanobiotechnology · 2026Article
- Oligodendrocyte transcription factor 2 orchestrates glioblastoma immune evasion by suppressing CXCL10 and CD8+ T cell activation.The Journal of clinical investigation · 2026Article
- Microglial HVCN1 Deficiency Improves Movement and Survival of SOD1Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- CRMP2 inhibits metastasis formation by impairing ILF3-dependent stabilization of CXCL10 mRNA in breast cancer.Cell death & disease · 2026Article
- Neuro-Immune Crosstalk: Molecular Mechanisms, Biological Functions, Diseases, and Therapeutic Targets.MedComm · 2026Review
- T cell acute lymphoblastic leukemia exploits a neural proinflammatory pathway to colonize the meninges.The Journal of clinical investigation · 2026Article
- Microglial TBK1 Signaling Promotes Breast Cancer Brain Metastasis.Cancer research · 2026Article
- Immune architecture of colorectal cancer brain metastases: spatial TAM heterogeneity and PD-L1 dynamics.Frontiers in immunology · 2026Article
- Crosstalk in the brain tumor microenvironment: mechanisms, therapeutic strategies, and clinical advances.Military Medical Research · 2026Review
- Bidirectional roles of meningeal lymphatic vessels in brain metastases: friend and foe.Frontiers in oncology · 2026Review
62 more citing papers are in PubMed but not listed here.
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Authors and funding
18 authors at 3 institutions in 1 country.
Ian H GuldnerDepartment of Biological Sciences, College of Science, University of Notre Dame, Notre Dame, IN 46556, USA; Mike and Josie Harper Cancer Research Institute, University of Notre Dame, South Bend, IN 46617, USA.
Qingfei WangDepartment of Biological Sciences, College of Science, University of Notre Dame, Notre Dame, IN 46556, USA; Mike and Josie Harper Cancer Research Institute, University of Notre Dame, South Bend, IN 46617, USA.
Lin YangMike and Josie Harper Cancer Research Institute, University of Notre Dame, South Bend, IN 46617, USA; Department of Computer Science and Engineering, College of Engineering, University of Notre Dame, Notre Dame, IN 46556, USA.
Samantha M GolombDepartment of Biological Sciences, College of Science, University of Notre Dame, Notre Dame, IN 46556, USA; Mike and Josie Harper Cancer Research Institute, University of Notre Dame, South Bend, IN 46617, USA.
Zhuo ZhaoMike and Josie Harper Cancer Research Institute, University of Notre Dame, South Bend, IN 46617, USA; Department of Computer Science and Engineering, College of Engineering, University of Notre Dame, Notre Dame, IN 46556, USA.
Jacqueline A LopezDepartment of Biological Sciences, College of Science, University of Notre Dame, Notre Dame, IN 46556, USA.
Abigail BrunoryDepartment of Biological Sciences, College of Science, University of Notre Dame, Notre Dame, IN 46556, USA; Mike and Josie Harper Cancer Research Institute, University of Notre Dame, South Bend, IN 46617, USA.
Erin N HoweDepartment of Biological Sciences, College of Science, University of Notre Dame, Notre Dame, IN 46556, USA; Mike and Josie Harper Cancer Research Institute, University of Notre Dame, South Bend, IN 46617, USA.
Yizhe ZhangMike and Josie Harper Cancer Research Institute, University of Notre Dame, South Bend, IN 46617, USA; Department of Computer Science and Engineering, College of Engineering, University of Notre Dame, Notre Dame, IN 46556, USA.
Bhavana PalakurthiDepartment of Biological Sciences, College of Science, University of Notre Dame, Notre Dame, IN 46556, USA; Mike and Josie Harper Cancer Research Institute, University of Notre Dame, South Bend, IN 46617, USA.
Martin BarronMike and Josie Harper Cancer Research Institute, University of Notre Dame, South Bend, IN 46617, USA; Department of Applied and Computational Mathematics and Statistics, University of Notre Dame, Notre Dame, IN 46556, USA.
Hongyu GaoDepartment of Medical and Molecular Genetics, Indiana University, Indianapolis, IN 46202, USA; Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, IN 46202, USA.
Xiaoling XueiDepartment of Medical and Molecular Genetics, Indiana University, Indianapolis, IN 46202, USA; Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, IN 46202, USA.
Yunlong LiuDepartment of Medical and Molecular Genetics, Indiana University, Indianapolis, IN 46202, USA; Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, IN 46202, USA.
Jun LiMike and Josie Harper Cancer Research Institute, University of Notre Dame, South Bend, IN 46617, USA; Department of Applied and Computational Mathematics and Statistics, University of Notre Dame, Notre Dame, IN 46556, USA.
Danny Z ChenMike and Josie Harper Cancer Research Institute, University of Notre Dame, South Bend, IN 46617, USA; Department of Computer Science and Engineering, College of Engineering, University of Notre Dame, Notre Dame, IN 46556, USA.
Gary E LandrethIndiana University School of Medicine Stark Neuroscience Research Institute, Indianapolis, IN 46202, USA.
Siyuan ZhangDepartment of Biological Sciences, College of Science, University of Notre Dame, Notre Dame, IN 46556, USA; Mike and Josie Harper Cancer Research Institute, University of Notre Dame, South Bend, IN 46617, USA; Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, IN 46202, USA. Electronic address: szhang8@nd.edu.
University of Notre Dame · USIndiana University – Purdue University Indianapolis · USCancer Research Institute · US
Funding
Mechanisms of neuroinflammation in brain metastasis progressionR01CA222405 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI ZHANG, SIYUAN · 2018 to 2022
$2.2M(PQD-3) Spatiotemporal Molecular Interrogation of Early Metastatic Evolution In SituR01CA194697 · NCI · UNIVERSITY OF NOTRE DAME · PI ZHANG, SIYUAN · 2015 to 2018
$1.4MNCI NIH HHS R01 CA194697NCI NIH HHS R01 CA222405
Abstract
Brain metastasis (br-met) develops in an immunologically unique br-met niche. Central nervous system-native myeloid cells (CNS-myeloids) and bone-marrow-derived myeloid cells (BMDMs) cooperatively regulate brain immunity. The phenotypic heterogeneity and specific roles of these myeloid subsets in shaping the br-met niche to regulate br-met outgrowth have not been fully revealed. Applying multimodal single-cell analyses, we elucidated a heterogeneous but spatially defined CNS-myeloid response during br-met outgrowth. We found Ccr2
Indexed as
Immunosuppression TherapyAnimalsBone Marrow CellsBrain NeoplasmsCentral Nervous SystemChemokine CXCL10CX3C Chemokine Receptor 1FemaleGene Expression ProfilingGene Expression Regulation, NeoplasticHumansInterferonsMacrophagesMembrane ProteinsMice, Inbred C57BLMice, KnockoutChemokine CXCL10CX3C Chemokine Receptor 1Cx3cr1 protein, mouseInterferonsMembrane ProteinsVsir protein, mousebone marrow-derived myeloid cellsbrain immunityBrain metastasiscancer immunologyimmune suppressionimmune therapymetastatic nichemicrogliaT cellstumor microenvironment
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.