Observational studyInternational urology and nephrology2021
The prognostic value of platelet-to-lymphocyte ratio on the long-term renal survival in patients with IgA nephropathy.
Observational study in International urology and nephrology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Prognostic Value of the HALP Score Compared with Other Inflammatory and Nutritional Indices in IgA Nephropathy.International journal of general medicine · 2026Article
- A predictive model based on routine blood inflammatory markers for IgA vasculitis in children.Frontiers in pediatrics · 2026Article
- The importance of the degree of foot process effacement in evaluating the prognosis of IgA nephropathy.International urology and nephrology · 2025Article
- Exploring the causal association between circulating leukocyte count and IgA nephropathy based on two-sample Mendelian randomization: possible role of transitional B cells.Clinical and experimental nephrology · 2025Article
- Article
- Impact of platelet-lymphocyte ratio after robot-assisted partial nephrectomy with renorrhaphy.Scientific reports · 2024Article
- Relationship between IgM deposition in the mesangial region and the prognosis of IgA nephropathy: a single-centre retrospective study.BMC nephrology · 2024Article
- The hemoglobin, albumin, lymphocyte, and platelet (HALP) score is associated with severe renal tubular atrophy/interstitial fibrosis in IgA nephropathy.European journal of medical research · 2024Article
- Are Platelet-Related Parameters Prognostic Predictors of Renal and Cardiovascular Outcomes in IgA Nephropathy?Journal of clinical medicine · 2024Article
- Correlation of Different Serum Biomarkers with Prediction of Early Pancreatic Graft Dysfunction Following Simultaneous Pancreas and Kidney Transplantation.Journal of clinical medicine · 2022Article
- Sexual Effect of Platelet-to-Lymphocyte Ratio in Predicting Cardiovascular Mortality of Peritoneal Dialysis Patients.Mediators of inflammation · 2022Article
- Platelet-to-lymphocyte ratio and prediction of progressive IgA nephropathy: myth or fact?International urology and nephrology · 2021Article
- Clinical and Histopathological Factors Influencing IgA Nephropathy Outcome.Diagnostics (Basel, Switzerland) · 2021Article
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12 authors.
Funding
Abstract
purposePlatelet-to-lymphocyte ratio (PLR) was established showing the poor prognosis in several diseases, such as malignancies and cardiovascular diseases. But limited study has been conducted about the prognostic value of PLR on the long-term renal survival of patients with Immunoglobulin A nephropathy (IgAN).
methodsWe performed an observational cohort study enrolling patients with biopsy-proven IgAN recorded from November 2011 to March 2016. The definition of composite endpoint was eGFR decrease by 50%, eGFR < 15 mL/min/1.73 m
results330 patients with a median age of 34.0 years were followed for a median of 47.4 months, and 27 patients (8.2%) had reached the composite endpoints. There were no differences among the three groups (PLR < 106, 106 ≤ PLR ≤ 137, and PLR > 137) in demographic characteristics, mean arterial pressure (MAP), proteinuria, and estimated glomerular filtration rate (eGFR) at baseline. The Kaplan-Meier curves showed that the PLR > 137 group was significantly more likely to poor renal outcomes than the other two groups. Using univariate and multivariate cox regression analyses, we found that PLR > 137 was an independent prognostic factor for poor renal survival in patients with IgAN. Subgroup analysis revealed that the PLR remained the prognostic value for female patients or patients with eGFR less than 60 mL/min/1.73 m
conclusionsOur results underscored that baseline PLR was an independent prognostic factor for poor renal survival in patients with IgAN, especially for female patients or those patients with baseline eGFR less than 60 mL/min/1.73 m
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