Evidence map›Paper›PMID 33113073›Full record

ArticleCancer causes & control : CCC2021

Socioeconomic status and childhood central nervous system tumors in California.

Stephen S Francis, Rong Wang, Catherine Enders, Isabel Prado, Joseph L Wiemels, Xiaomei Ma, Catherine Metayer

Abstract read
PubMed Publisher
In one paragraph

Article in Cancer causes & control : CCC, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Frontiers in immunology · 2025
    Article
  6. Observational
  7. Review
  8. Article
  9. Article
  10. Pediatric Cancer By Race, Ethnicity and Region in the United States.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2022
    Article
  11. Article
  12. Article
  13. Epidemiology of Brain and Other CNS Tumors.Current neurology and neuroscience reports · 2021
    Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Stephen S FrancisDepartment of Neurological Surgery, Helen Diller Comprehensive Cancer Center, University of California, San Francisco, 1450 3rd St, HD483, San Francisco, CA, 94158, USA. Stephen.francis@ucsf.edu.
Rong WangDepartment of Chronic Disease Epidemiology, School of Public Health, Yale University, New Haven, USA.
Catherine EndersDepartment of Epidemiology and Biostatistics, University of California, Berkeley, USA.
Isabel PradoDepartment of Chronic Disease Epidemiology, School of Public Health, Yale University, New Haven, USA.
Joseph L WiemelsCenter of Genetic Epidemiology, University of Southern California, Los Angeles, USA.
Xiaomei MaDepartment of Chronic Disease Epidemiology, School of Public Health, Yale University, New Haven, USA.
Catherine MetayerDepartment of Epidemiology and Biostatistics, University of California, Berkeley, USA.
Yale University · USUniversity of California, Berkeley · USUCSF Helen Diller Family Comprehensive Cancer Center · USUniversity of Southern California · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeChildhood central nervous system (CNS) tumors are the leading cause of cancer mortality in children. Previous studies have suggested that some childhood cancers, including primary CNS tumors, may be associated with higher socioeconomic status (SES).

methodsWe linked data from the California Cancer Registry to California birth records for children (age 0-19 years) diagnosed with primary CNS tumors during 1988-2011 and analyzed multiple measures of parental SES around the birth of their children and subsequent risk for childhood CNS tumors. Our SES measures included birth record-derived parental education and insurance utilization. For a subset of subjects born between 1997 and 2007, we geocoded addresses and examined census-derived median household income and educational level.

resultsWe analyzed data for 3,022 children with primary CNS tumors and 10,791 matched controls. We found consistent evidence across multiple measures that lower estimates of SES are associated with a reduced risk of CNS tumors. In tumor subgroup analyses, this relationship was most consistent in astrocytomas and ependymomas, with varying findings for embryonal tumors.

conclusionHigher parental SES appears to be a risk factor for childhood CNS tumors in California. Further research is needed to determine specific exposures that may explain this increased risk.

Indexed as

Central Nervous System NeoplasmsAdolescentCaliforniaChildChild, PreschoolEducational StatusFemaleHumansIncomeInfantInfant, NewbornMaleRegistriesRisk FactorsSocial ClassYoung AdultBrain tumorsChildhood CNS tumorsEpidemiologySocioeconomic status

Identifiers

PMID33113073
OpenAlexW3096009383

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.