ArticleEnvironmental science and pollution research international2021
Immunodetection of heat shock protein 70 and cell death in liver of a neotropical fish acutely and chronically exposed to acetaminophen and propranolol.
Article in Environmental science and pollution research international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed, 7 citations in OpenAlex.
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5 authors at 2 institutions in 2 countries.
Funding
Abstract
The use of pharmaceutical drugs ends frequently in their inappropriate disposal and treatment at waste water treatment plants, which is the cause of their widespread presence in the environment. Yet, there is limited understanding or knowledge of their effects to non-target aquatic organisms. The drugs acetaminophen (analgesic and antipyretic) and propranolol (β-blocker) are widely found in the aquatic environment, where they can interact with non-target exposed organisms, causing adverse effects. Heat shock proteins (namely HSP70) are molecular chaperones which help to refold misfolded cellular proteins, and the increase in their in vivo levels indicates a change in the cell to counteract the proteotoxic effects of the triggered stress, namely which is consequent to exposure to toxicants. The objective of this study was to quantify the levels of liver HSP70 proteins in individuals of the neotropical fish species Phalloceros harpagos, acutely and chronically exposed to concentrations of acetaminophen and propranolol, in the range of those already determined to occur in the wild. Fish acutely exposed to acetaminophen (concentrations of 8, 80, 800, and 8000 μg L
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