Evidence map›Paper›PMID 33112907›Full record

ArticlePloS one2020

Knowledge and barriers of PrEP delivery among diverse groups of potential PrEP users in Central Uganda.

Timothy R Muwonge, Rogers Nsubuga, Charles Brown, Agnes Nakyanzi, Monica Bagaya, Felix Bambia, Elly Katabira, Peter Kyambadde, Jared M Baeten, Renee Heffron and 3 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05516602 (Improving HIV Prevention Among Adolescent Girls and Young Women), which is not on this map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
0.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05516602 nacompletednot on this mapstarted 2023, after this paper: background citation

Improving HIV Prevention Among Adolescent Girls and Young Women (AGYW) in Uganda

TypeinterventionalSponsorMRC/UVRI and LSHTM Uganda Research UnitRan2023 to 2024Enrolled394ConditionsHIV-1-infectionArmsPeer Support
3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 48 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Timothy R MuwongeInfectious Diseases Institute Makerere University, Kampala, Uganda.ORCID 0000-0002-8478-9234
Rogers NsubugaInfectious Diseases Institute Makerere University, Kampala, Uganda.
Charles BrownInfectious Diseases Institute Makerere University, Kampala, Uganda.
Agnes NakyanziInfectious Diseases Institute Makerere University, Kampala, Uganda.
Monica BagayaInfectious Diseases Institute Makerere University, Kampala, Uganda.
Felix BambiaInfectious Diseases Institute Makerere University, Kampala, Uganda.
Elly KatabiraDepartment of Medicine, College of Health Sciences, Makerere University, Kampala, Uganda.
Peter KyambaddeMost At-Risk Populations Initiative, Kampala, Uganda.
Jared M BaetenDepartment of Global Health, Medicine, and Epidemiology, University of Washington, Seattle, Washington, United States of America.
Renee HeffronDepartment of Global Health, Medicine, and Epidemiology, University of Washington, Seattle, Washington, United States of America.
Connie CelumDepartment of Global Health, Medicine, and Epidemiology, University of Washington, Seattle, Washington, United States of America.ORCID 0000-0002-8813-3419
Andrew MujugiraInfectious Diseases Institute Makerere University, Kampala, Uganda.
Jessica E HabererDepartment of General Internal Medicine, Massachusetts General Hospital Global Health, Boston, Massachusetts, United States of America.
Infectious Diseases Institute · UGUniversity of Washington · USMakerere University · UGMassachusetts General Hospital · USMinistry of Health · UG

Funding

University of Washington/Fred Hutch Center for AIDS ResearchP30AI027757 · NIAID · UNIVERSITY OF WASHINGTON · PI CONNIE L CELUM · 1988 to 2026
$104.9M
Real World Adherence to HIV PrEP in Serodiscordant African CouplesR01MH098744 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI HABERER, JESSICA ELIZABETH · 2013 to 2017
$3.0M
Optimizing mHealth for adherence monitoring and interventionK24MH114732 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI HABERER, JESSICA ELIZABETH · 2017 to 2021
$800k
NIAID NIH HHS P30 AI027757NIMH NIH HHS K24 MH114732NIMH NIH HHS R01 MH098744
6 · The paper itself

Abstract

backgroundScale-up of oral pre-exposure prophylaxis (PrEP) for HIV prevention in Uganda began with serodiscordant couples (SDC) and has expanded to other most at-risk populations (MARPs). We explored knowledge, acceptability, barriers and facilitators of PrEP use among potential PrEP users in four MARPs (SDC; men who have sex with men [MSM]; female sex workers [FSW], and fisher folk).

methodsWe administered quantitative surveys to potential PrEP users in multiple settings in Central Uganda at baseline and approximately 9 months after healthcare worker (HCW) training on PrEP.

resultsThe survey was completed by 250 potential PrEP users at baseline and 125 after HCW training; 55 completed both surveys. For these 250 participants, mean age was 28.5 years (SD 6.9), 47% were male and 6% were transgender women, with approximately even distribution across MARPs and recruitment locations (urban, peri-urban, and rural). Most (65%) had not heard about PrEP. After HCW training, 24% of those sampled were aware of PrEP, and the proportion of those who accurately described PrEP as "antiretrovirals to be used before HIV exposure" increased from 54% in the baseline survey to 74% in the second survey (p<0.001). The proportion of participants who reported HCW as a source of PrEP information increased after training (59% vs 91%, p<0.001). In both surveys, nearly all participants indicated they were willing to take PrEP if offered. The most common anticipated barriers to PrEP were stigma, transportation, accessibility, busy schedules, and forgetfulness. Closeness to home was a common facilitator for all participant categories.

conclusionsInitial awareness of PrEP was low, but PrEP knowledge and interest increased among diverse MARPs after HCW training. Demand creation and HCW training will be critical for increasing PrEP awareness among key populations, with support to overcome barriers to PrEP use. These findings should encourage the acceleration of PrEP rollout in Uganda.

Indexed as

Health Knowledge, Attitudes, PracticeAdministration, OralAdultEmtricitabineFemaleHealth Services AccessibilityHIV InfectionsHumansMalePatient CompliancePre-Exposure ProphylaxisSurveys and QuestionnairesTenofovirUgandaEmtricitabineTenofovir

Identifiers

PMID33112907
PMCPMC7592843
OpenAlexW3096408626

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.