ArticlePloS one2020
Potentially inappropriate medications for the elderly: Incidence and impact on mortality in a cohort ten-year follow-up.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 46 citations in OpenAlex.
- Evaluation of polypharmacy and potentially inappropriate medication use among geriatric individuals aged 80 years and older.BMC geriatrics · 2026Article
- A Prospective Study on Potentially Inappropriate Drug Use and All-Cause Mortality in Community-Dwelling Older Adults.Journal of the American Geriatrics Society · 2025Article
- Incidence of Potentially Inappropriate Prescribing: Longitudinal Investigation of Outpatient EHR Prescriptions.Journal of the American Geriatrics Society · 2025Article
- Classifying Polypharmacy According to Pharmacotherapeutic and Clinical Risks in Older Adults: A Latent Class Analysis in Quebec, Canada.Drugs & aging · 2023Article
- Overuse of medications in low- and middle-income countries: a scoping review.Bulletin of the World Health Organization · 2023Article
- Geriatrician-led multidisciplinary team management improving polypharmacy among older inpatients in China.Frontiers in pharmacology · 2023Article
- Does Abdominal Obesity Increase All-Cause, Cardiovascular Disease, and Cancer Mortality Risks in Older Adults? A 10-Year Follow-Up Analysis.Nutrients · 2022Article
- Risk factors for potentially inappropriate medication use in older adults: a cohort study.International journal of clinical pharmacy · 2022Article
- Article
- The patterns and implications of potentially suboptimal medicine regimens among older adults: a narrative review.Therapeutic advances in drug safety · 2022Review
- Questionnaire-based Pan-India survey for impact assessment of National Formulary of India.Indian journal of pharmacologyArticle
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionPharmacological therapy plays an important role in disease control in the elderly; unfortunately, this comes with a high prevalence in the use of medications classified as potentially inappropriate.
objectiveTo analyze the incidence, risk factors, and survival of elderly people using potentially inappropriate medications (PIM).
methodA ten-year follow-up assessment of elderly participants residing in a capital of Central Brazil was conducted. The initial assessment (baseline) included 418 elderly people. Data were collected through home interviews guided by a questionnaire covering socioeconomic, demographic, living conditions, and health variables. The medication information obtained comprised active ingredient, dosage, route, and regimen for the medications. The PIMs were classified according to 2019 Beers Criteria. The analyses were performed using STATA 15.0. For survival analysis, a Cox Regression was performed with the respective Kaplan Meier curve.
resultsThe incidence of PIM was 44.1 cases (95% CI: 35.2-54.7) per 1,000 people a year. The most used PIMs were nifedipine, glibenclamide, and sodium diclofenac. The risk factors were polypharmacy (aRR: 3.00; 95% CI: 1.31-6.88) and diabetes mellitus (aRR: 1.57; 95% CI: 1.03-2.39). We identified no statistically significant association between survival and the use of PIM.
conclusionThe study highlights the high consumption of PIM among the elderly causing polypharmacy risks. Health professionals working in drug treatment need to be alert to polypharmacy risks to ensure the rational use of medications to prevent adverse reactions and other health problems.
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