Evidence map›Paper›PMID 33112721›Full record

ArticleMolecular imaging

Magnetofluorescent Nanoprobe for Multimodal and Multicolor Bioimaging.

Aditya Yadav, Chethana Rao, Navneet Chandra Verma, Pushpendra Mani Mishra, Chayan Kanti Nandi

Abstract read
In one paragraph

Article in Molecular imaging. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Aditya YadavSchool of Basic Sciences, Indian Institute of Technology Mandi, Himachal Pradesh, India.
Chethana RaoSchool of Basic Sciences, Indian Institute of Technology Mandi, Himachal Pradesh, India.
Navneet Chandra VermaSchool of Basic Sciences, Indian Institute of Technology Mandi, Himachal Pradesh, India.
Pushpendra Mani MishraSchool of Basic Sciences, Indian Institute of Technology Mandi, Himachal Pradesh, India.
Chayan Kanti NandiSchool of Basic Sciences, Indian Institute of Technology Mandi, Himachal Pradesh, India.ORCID 0000-0002-4584-0738

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although, superparamagnetic iron oxide nanoparticles (SPIONs) have extensively been used as a contrasting agent for magnetic resonance imaging (MRI), the lack of intrinsic fluorescence restricted their application as a multimodal probe, especially in combination with light microscopy. In Addition, the bigger size of the particle renders them incompetent for bioimaging of small organelles. Herein, we report, not only the synthesis of ultrasmall carbon containing magneto-fluorescent SPIONs with size ∼5 nm, but also demonstrate its capability as a multicolor imaging probe. Using MCF-7 and HeLa cell lines, we show that the SPIONs can provide high contrast mulicolor images of the cytoplasm from blue to red region. Further, single particle level photon count data revealed that the SPIONs could efficaciously be utilized in localization based super resolution microscopy in future.

Indexed as

Magnetic Resonance ImagingFluorescenceHeLa CellsHumansfluorescent iron oxide nanoparticleslight microscopymulticolor emissionmultimodal bioimagingsingle particle photon count

Identifiers

PMID33112721
PMCPMC8865915

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.