Evidence map›Paper›PMID 33112695›Full record

ReviewGut microbes2020

Molecular insights into probiotic mechanisms of action employed against intestinal pathogenic bacteria.

Winschau F van Zyl, Shelly M Deane, Leon M T Dicks

Open access · goldAbstract readReview
In one paragraph

Review in Gut microbes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 177 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
177citing papers in PubMed, 1 pooled it
23.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

177 citing papers in PubMed, 1 synthesis or guideline pooled it, 318 citations in OpenAlex.

  1. Pooled it
  2. Therapeutic Potential ofInternational journal of molecular sciences · 2025
    Trial
  3. Trial
  4. Review
  5. Article
  6. Article
  7. Exploring the Adhesion Potential ofFoods (Basel, Switzerland) · 2026
    Article
  8. Article
  9. Review
  10. Microorganisms · 2026
    Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. MitigatingMicroorganisms · 2026
    Review

117 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Winschau F van ZylDepartment of Microbiology, Stellenbosch University , Stellenbosch, South Africa.
Shelly M DeaneDepartment of Microbiology, Stellenbosch University , Stellenbosch, South Africa.
Leon M T DicksDepartment of Microbiology, Stellenbosch University , Stellenbosch, South Africa.
Stellenbosch University · ZA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gastrointestinal (GI) diseases, and in particular those caused by bacterial infections, are a major cause of morbidity and mortality worldwide. Treatment is becoming increasingly difficult due to the increase in number of species that have developed resistance to antibiotics. Probiotic lactic acid bacteria (LAB) have considerable potential as alternatives to antibiotics, both in prophylactic and therapeutic applications. Several studies have documented a reduction, or prevention, of GI diseases by probiotic bacteria. Since the activities of probiotic bacteria are closely linked with conditions in the host's GI-tract (GIT) and changes in the population of enteric microorganisms, a deeper understanding of gut-microbial interactions is required in the selection of the most suitable probiotic. This necessitates a deeper understanding of the molecular capabilities of probiotic bacteria. In this review, we explore how probiotic microorganisms interact with enteric pathogens in the GIT. The significance of probiotic colonization and persistence in the GIT is also addressed.

Indexed as

AnimalsGastrointestinal DiseasesGastrointestinal TractHumansLactobacillalesProbioticsantimicrobial compoundsbacteriocinscolonizationcompetitive exclusionenteric pathogensgastrointestinal tractlactic acid bacteriaProbiotics

Identifiers

PMID33112695
PMCPMC7595611
OpenAlexW3097663811

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.