Evidence map›Paper›PMID 33112694›Full record

ReviewJournal of child neurology2021

A Comprehensive Review of Neurologic Manifestations of COVID-19 and Management of Pre-existing Neurologic Disorders in Children.

Yunsung Kim, Sarah A Walser, Sheila J Asghar, Rohit Jain, Gayatra Mainali, Ashutosh Kumar

Open access · hybridAbstract readReview
In one paragraph

Review in Journal of child neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Observational
  5. Review
  6. Review
  7. Coronavirus Infection in Neonates: Neurodevelopmental Outcomes at 18 Months of Age.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2023
    Article
  8. Article
  9. Article
  10. Medication-resistant acute focal motor seizures in a child with COVID-19 affecting the CNSEpileptic disorders : international epilepsy journal with videotape · 2022
    Article
  11. Article
  12. Neurological effects of COVID-19 in infants and children.Developmental medicine and child neurology · 2022
    Review
  13. Review
  14. Article
  15. Article
  16. Review
  17. Neurologic Care of COVID-19 in Children.Frontiers in neurology · 2020
    Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Yunsung Kim12310Penn State College of Medicine Medical Scientist Training Program, Hershey, PA, USA.ORCID 0000-0002-6935-390X
Sarah A Walser12310Penn State College of Medicine, University Park, PA, USA.
Sheila J AsgharDepartment of Neurology, 23346Louisiana State University Health, Shreveport, LA, USA.
Rohit JainDepartment of Hospital Medicine, 12311Penn State Health Milton Hershey Medical Center, Hershey, PA, USA.
Gayatra MainaliDepartment of Pediatrics and Neurology, 12311Penn State Health Milton Hershey Medical Center, Hershey, PA, USA.
Ashutosh KumarDepartment of Pediatrics and Neurology, 12311Penn State Health Milton Hershey Medical Center, Hershey, PA, USA.
Penn State Milton S. Hershey Medical Center · USLouisiana State University · USPennsylvania State University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Since the first reports of SARS-CoV-2 infection from China, multiple studies have been published regarding the epidemiologic aspects of COVID-19 including clinical manifestations and outcomes. The majority of these studies have focused on respiratory complications. However, recent findings have highlighted the systemic effects of the virus, including its potential impact on the nervous system. Similar to SARS-CoV-1, cellular entry of SARS-CoV-2 depends on the expression of ACE2, a receptor that is abundantly expressed in the nervous system. Neurologic manifestations in adults include cerebrovascular insults, encephalitis or encephalopathy, and neuromuscular disorders. However, the presence of these neurologic findings in the pediatric population is unclear. In this review, the potential neurotropism of SARS-CoV-2, known neurologic manifestations of COVID-19 in children, and management of preexisting pediatric neurologic conditions during the COVID-19 pandemic are discussed.

Indexed as

AdolescentAge FactorsChildChild, PreschoolCOVID-19HumansInfantInfant, NewbornNervous System DiseasesChildrenCOVID-19EncephalitisNeuroimmunologyNeurologicalPediatricSARS-CoV-2Treatment

Identifiers

PMID33112694
PMCPMC7859660
OpenAlexW3097465988

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.