Evidence map›Paper›PMID 33112562›Full record

ArticleAsian Pacific journal of cancer prevention : APJCP2020

Serum micro-RNA Identifies Early Stage Colorectal Cancer in a Multi-Ethnic Population.

Jessica Shiosaki, Maarit Tiirikainen, Karolina Peplowska, David Shaeffer, Michio Machida, Kazuhiro Sakamoto, Makoto Takahashi, Kuniaki Kojima, Junji Machi, Peter Bryant-Greenwood and 1 more

Open access · goldAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Asian Pacific journal of cancer prevention : APJCP, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
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  11. MiR-29a-3p: a potential biomarker and therapeutic target in colorectal cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Jessica ShiosakiJohn A. Burns School of Medicine, University of Hawaii, 651 Ilalo Street, MEB, Honolulu, Hawaii, United States.
Maarit TiirikainenUniversity of Hawaii Cancer Center, 01 Ilalo Street, Honolulu, Hawaii, United States.
Karolina PeplowskaUniversity of Hawaii Cancer Center, 01 Ilalo Street, Honolulu, Hawaii, United States.
David ShaefferJohn A. Burns School of Medicine, University of Hawaii, 651 Ilalo Street, MEB, Honolulu, Hawaii, United States.
Michio MachidaJuntendo University, 3-1-3 Hongo, Bunkyo-ku, Tokyo, Japan.
Kazuhiro SakamotoJuntendo University, 3-1-3 Hongo, Bunkyo-ku, Tokyo, Japan.
Makoto TakahashiJuntendo University, 3-1-3 Hongo, Bunkyo-ku, Tokyo, Japan.
Kuniaki KojimaJuntendo University, 3-1-3 Hongo, Bunkyo-ku, Tokyo, Japan.
Junji MachiJohn A. Burns School of Medicine, University of Hawaii, 651 Ilalo Street, MEB, Honolulu, Hawaii, United States.
Peter Bryant-GreenwoodNational Jewish Health, 1400 Jackson Street, Denver, Colorado, United States.
Scott K KuwadaJohn A. Burns School of Medicine, University of Hawaii, 651 Ilalo Street, MEB, Honolulu, Hawaii, United States.
Juntendo University · JPUniversity of Hawaiʻi at Mānoa · USCancer Center of Hawaii · USNational Jewish Health · US

Funding

University of Hawaii Cancer Center CCSGP30CA071789 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI Xin Chen · 1996 to 2026
$56.2M
NCI NIH HHS P30 CA071789
6 · The paper itself

Abstract

objectiveCertain microRNAs (miR) have been previously described to be dysregulated in cancers and can be detected in blood samples. Studies examining the utility of miRs for colon cancer screening have primarily been performed in ethnically homogeneous groups of patients, thus the performance of miRs in multiethnic populations is unknown.

methodsFour miRs were selected that were shown to be aberrantly expressed in the blood or stool of patients with colorectal cancer (CRC) of various ethnicities. In this study, the ability of these miRs to discern early stage CRC was determined in a previously untested multiethnic population of 73 CRC cases and 18 controls.

resultsThe ratios of non-vesicular to extracellular vesicular levels of miR's -21, -29a, and -92a were statistically and quantitatively related to CRC stage compared to controls.

conclusionSerum levels of miR-21, miR-29a and miR-92a were able to significantly detect early stage CRC in a multiethnic and previously untested population.<br />.

Indexed as

AgedBiomarkers, TumorCase-Control StudiesColorectal NeoplasmsEthnicityFemaleFollow-Up StudiesGene Expression Regulation, NeoplasticHawaiiHumansJapanMaleMicroRNAsMiddle AgedPrognosisBiomarkers, TumorMicroRNAsMIRN21 microRNA, humanMIRN29a microRNA, humanMIRN92 microRNA, humancolorectal cancerDiagnosismicro-RNAmulti-ethnic

Identifiers

PMID33112562
PMCPMC7798181
OpenAlexW3096223133

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.