Evidence map›Paper›PMID 33112481›Full record

Trial reportJournal of paediatrics and child health2021

Faecal regenerating 1B protein concentration is not associated with child growth in rural Malawi.

Zhifei Liu, Yue-Mei Fan, Per Ashorn, Yin Bun Cheung, Lotta Hallamaa, Heikki Hyöty, Kenneth Maleta, Kirsi-Maarit Lehto, Sami Oikarinen, Seppo Parkkila and 1 more

Open access · hybridAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Journal of paediatrics and child health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 3 countries.

Zhifei LiuCenter for Child Health Research, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.ORCID 0000-0003-1824-7856
Yue-Mei FanCenter for Child Health Research, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Per AshornCenter for Child Health Research, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Yin Bun CheungCenter for Child Health Research, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Lotta HallamaaCenter for Child Health Research, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Heikki HyötyCenter for Child Health Research, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Kenneth MaletaDepartment of Public Health, School of Public Health & Family Medicine, College of Medicine, University of Malawi, Zomba, Malawi.
Kirsi-Maarit LehtoCenter for Child Health Research, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Sami OikarinenCenter for Child Health Research, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Seppo ParkkilaCenter for Child Health Research, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Ulla AshornCenter for Child Health Research, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Tampere University of Applied Sciences · FIUniversity of Malawi · MW

Funding

Bill & Melinda Gates FoundationCompetitive State Research Financing of the Expert Responsibility area of Tampere University HospitalFinnish Funding Agency for Technology and Innovation (TEKES)Lastentautien TutkimussäätiöUnited States Agency for International Development (USAID) AID-OAA-A-12-00005
6 · The paper itself

Abstract

aimThis study was designed to determine whether faecal regenerating 1B protein (REG1B) concentration is associated with physical growth among 6-30-month-old children in rural Malawi.

methodsThis was a secondary analysis from a randomised controlled trial in rural Malawi in which we followed-up 790 live-born infants from birth to 30 months of age. We collected anthropometric data at the age of 6, 12, 18, 24 and 30 months. We measured faecal REG1B concentration by enzyme-linked immunosorbent assay (ELISA) technique using stool samples collected at 6, 18 and 30 months of age. We assessed the association between faecal REG1B concentration and children's physical growth using linear regression and longitudinal data analysis.

resultsOf 790 live-born infants enrolled, 694 (87%) with at least one faecal REG1B concentration measurement were included in the analysis. Faecal REG1B concentration was not associated with the children's concurrent length-for-age z-score (LAZ), weight-for-age z-score (WAZ), weight-for-length z-score (WLZ) and mid-upper arm circumference-for-age z-score (MUACZ) at any time point (P > 0.05), nor with a change in their anthropometric indices in the subsequent 6-month period (P > 0.05).

conclusionsFaecal REG1B concentration is not associated with LAZ, WAZ, WLZ and MUACZ among 6-30-month-old infants and children in rural Malawi.

Indexed as

Body HeightLithostathineRural PopulationAnthropometryBody WeightChildChild, PreschoolFecesFemaleGrowthHumansInfantMalawiMalePregnancyLithostathineREG1B protein, humanchild growthintestinal repairregenerating 1B proteinrural Malawi

Identifiers

PMID33112481
PMCPMC8048694
OpenAlexW3094844588

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.