ArticleeLife2020
A small protein encoded by a putative lncRNA regulates apoptosis and tumorigenicity in human colorectal cancer cells.
Open access · goldAbstract read
In one paragraph
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed
5.2field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
60 citing papers in PubMed, 107 citations in OpenAlex.
- The identity crisis of cryptic lncRNAs: when non-coding RNAs translate into small peptides.The EMBO journal · 2026Review
- Article
- Integrative analysis of RNA-seq and Ribo-seq reveals that lncRNA regulates chicken myogenesis through encoding peptide.Journal of animal science and biotechnology · 2026Article
- Conserved structural features of the lncRNA HOTAIR in breast cancer cells.bioRxiv : the preprint server for biology · 2026Article
- Recent advances in structural and functional diversities of cancer lncRNA-encoded peptides: current opportunities and challenges for enhancing cancer diagnosis and treatment.Cancer cell international · 2026Review
- Construction of a novel ferroptosis-related long non-coding RNAs model for predicting prognosis and tumor immune microenvironment in endometrial cancer.Annals of translational medicine · 2025Article
- Mitochondrial Microproteins: Emerging Regulators in Neurodevelopment and Neurodegeneration.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025Review
- Emerging roles for microproteins as critical regulators of endoplasmic reticulum function and cellular homeostasis.Seminars in cell & developmental biology · 2025Review
- Proteomic Analysis of Invasive Breast Cancer Cells Treated with CBD Reveals Proteins Associated with the Reversal of Their Epithelial-Mesenchymal Transition Induced by IL-1β.International journal of molecular sciences · 2025Article
- Identification of Small Open Reading Frame-encoded Proteins in the Human Genome.Genomics, proteomics & bioinformatics · 2025Article
- Beyond the Transcript: Translating Non-Coding RNAs and Their Impact on Cellular Regulation.Cancers · 2025Review
- Current Perspectives on Functional Involvement of Micropeptides in Virus-Host Interactions.International journal of molecular sciences · 2025Review
- Small open reading frame-encoded microproteins in cancer: identification, biological functions and clinical significance.Molecular cancer · 2025Review
- Noncoding RNA-encoded peptides in cancer: biological functions, posttranslational modifications and therapeutic potential.Journal of hematology & oncology · 2025Review
- Microproteins in cancer: identification, biological functions, and clinical implications.Trends in genetics : TIG · 2025Review
- Identification of a Novel Intracellular Function of the Secreted Ribonuclease RNASE1 in Inhibiting Gene Expression.Molecular and cellular biology · 2025Article
- Identification of long noncoding RNAs (lncRNAs) and co-transcriptional analysis of mRNAs and lncRNAs in transcriptomes ofFrontiers in RNA research · 2025Article
- Endogenous micropeptides as potential diagnostic biomarkers and therapeutic drugs.Frontiers in pharmacology · 2025Review
- The clinicopathological significance of BRI3BP in women with invasive breast cancer.Translational cancer research · 2024Article
- Thousands of oscillating LncRNAs in the mouse testis.Computational and structural biotechnology journal · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
29 authors at 8 institutions in 1 country.
Xiao Ling LiRegulatory RNAs and Cancer Section, Genetics Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, United States.
Lőrinc PongorDevelopmental Therapeutics Branch, CCR, NCI, NIH, Bethesda, United States.ORCID 0000-0001-5917-4628
Wei TangMolecular Epidemiology Section, Laboratory of Human Carcinogenesis, CCR, NCI, NIH, Bethesda, United States.
Sudipto DasProtein Characterization Laboratory, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc, Frederick, United States.
Bruna R MuysRegulatory RNAs and Cancer Section, Genetics Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, United States.
Matthew F JonesRegulatory RNAs and Cancer Section, Genetics Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, United States.
Sarah B LazarRegulatory RNAs and Cancer Section, Genetics Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, United States.
Emily A DangelmaierRegulatory RNAs and Cancer Section, Genetics Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, United States.ORCID 0000-0002-4698-2500
Corrine Cr HartfordRegulatory RNAs and Cancer Section, Genetics Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, United States.
Ioannis GrammatikakisRegulatory RNAs and Cancer Section, Genetics Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, United States.ORCID 0000-0002-8455-1584
Qinyu HaoDepartment of Cell and Developmental Biology, Cancer Center at Illinois University of Illinois at Urbana-Champaign, Urbana, United States.ORCID 0000-0002-7059-7741
Qinyu SunDepartment of Cell and Developmental Biology, Cancer Center at Illinois University of Illinois at Urbana-Champaign, Urbana, United States.
Aaron SchetterMolecular Genetics and Carcinogenesis Section, Laboratory of Human Carcinogenesis, CCR, NCI, NIH, Bethesda, United States.
Jennifer L MartindaleLaboratory of Genetics and Genomics, National Institute on Aging Intramural Research Program, NIH, Baltimore, United States.
BinWu TangLaboratory of Cancer Biology and Genetics, CCR, NCI, NIH, Bethesda, United States.
Lisa M JenkinsLaboratory of Cell Biology, CCR, NCI, NIH, Bethesda, United States.
Ana I RoblesMolecular Genetics and Carcinogenesis Section, Laboratory of Human Carcinogenesis, CCR, NCI, NIH, Bethesda, United States.
Robert L WalkerMolecular Genetics Section, Genetics Branch, CCR, NCI, NIH, Bethesda, United States.
Stefan AmbsMolecular Epidemiology Section, Laboratory of Human Carcinogenesis, CCR, NCI, NIH, Bethesda, United States.
Raj ChariGenome Modification Core, Frederick National Lab for Cancer Research, National Cancer Institute, Frederick, United States.
Svetlana A ShabalinaNational Center for Biotechnology Information, National Library of Medicine, NIH, Bethesda, United States.
Myriam GorospeLaboratory of Genetics and Genomics, National Institute on Aging Intramural Research Program, NIH, Baltimore, United States.
S Perwez HussainPancreatic Cancer Unit, Laboratory of Human Carcinogenesis, CCR, NCI, NIH, Bethesda, United States.
Curtis C HarrisMolecular Genetics and Carcinogenesis Section, Laboratory of Human Carcinogenesis, CCR, NCI, NIH, Bethesda, United States.
Paul S MeltzerMolecular Genetics Section, Genetics Branch, CCR, NCI, NIH, Bethesda, United States.
Kannanganattu V PrasanthDepartment of Cell and Developmental Biology, Cancer Center at Illinois University of Illinois at Urbana-Champaign, Urbana, United States.ORCID 0000-0003-4587-8362
Mirit I AladjemDevelopmental Therapeutics Branch, CCR, NCI, NIH, Bethesda, United States.
Thorkell AndressonProtein Characterization Laboratory, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc, Frederick, United States.
Ashish LalRegulatory RNAs and Cancer Section, Genetics Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, United States.ORCID 0000-0002-4299-8177
National Institutes of Health · USCenter for Cancer Research · USUniversity of Illinois Urbana-Champaign · USInstitute on Aging · USLeidos (United States) · USFrederick National Laboratory for Cancer Research · USGenesis Foundation · USNational Center for Biotechnology Information · US
Funding
Role of long non-coding RNAs in p53 signalingZIABC011646 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI LAL, ASHISH · 2015 to 2025
$15.0MCharacterization of nuclear-retained RNA-mediated gene regulatory mechanismsR01GM132458 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI KANNANGANATTU, PRASANTH KUMAR VIJAYAN · 2020 to 2023
$1.4MMonoalleleic autosomal spreading of a novel family of nucleolus-localized ncRNAsR21AG065748 · NIA · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI KANNANGANATTU, PRASANTH KUMAR VIJAYAN · 2020 to 2021
$423kIntramural NIH HHS ZIA BC011646NIA NIH HHS R21 AG065748NIGMS NIH HHS R01 GM132458NIH HHS ZIA BC 011646
Abstract
Long noncoding RNAs (lncRNAs) are often associated with polysomes, indicating coding potential. However, only a handful of endogenous proteins encoded by putative lncRNAs have been identified and assigned a function. Here, we report the discovery of a putative gastrointestinal-tract-specific lncRNA (
Indexed as
ApoptosisCarcinogenesisCell Line, TumorCell ProliferationColorectal NeoplasmsEndoplasmic ReticulumEndoplasmic Reticulum StressGastrointestinal TractGenes, ReporterHepatocyte Nuclear Factor 3-alphaHumansMolecular Sequence AnnotationOrgan SpecificityRNA, Long NoncodingFOXA1 protein, humanHepatocyte Nuclear Factor 3-alphalong non-coding RNA Linc00675, humanRNA, Long Noncodingcancer biologychromosomesCRCFOXA1gene expressionhumanLINC00675lncRNAmicropeptideORF
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC0
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.