ArticleJournal of clinical laboratory analysis2021
Laboratory markers associated with COVID-19 progression in patients with or without comorbidity: A retrospective study.
Article in Journal of clinical laboratory analysis, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- The inflammatory markers of multisystem inflammatory syndrome in children (MIS-C) and adolescents associated with COVID-19: A meta-analysis.Journal of medical virology · 2021Pooled it
- Clinical Significance of Plasma D-Dimer in COVID-19 Mortality.Frontiers in medicine · 2021Pooled it
- Serum Prealbumin Concentrations, COVID-19 Severity, and Mortality: A Systematic Review and Meta-Analysis.Frontiers in medicine · 2021Pooled it
- FIB-4 Index Can Predict Mortality in Hospitalized Patients with COVID-19 Infection, Independent of CT Severity Score.Archives of Iranian medicine · 2025Article
- Single-cell RNA-seq combined with bulk RNA-seq explores shared gene signatures between thyroid and breast cancers.Frontiers in genetics · 2025Article
- Creatine Kinase as a Predictor of Disease Severity in Children with COVID-19.Medical journal of the Islamic Republic of Iran · 2025Article
- Lab results of COVID-19 patients: OmicronWorld journal of virology · 2024Article
- Association between Fibrinogen-to-Albumin Ratio and Prognosis of Hospitalized Patients with COVID-19: A Systematic Review and Meta-Analysis.Diagnostics (Basel, Switzerland) · 2022Review
- Heterogeneity and Risk of Bias in Studies Examining Risk Factors for Severe Illness and Death in COVID-19: A Systematic Review and Meta-Analysis.Pathogens (Basel, Switzerland) · 2022Review
- Meta-Analysis and Systematic Review of Coagulation Disbalances in COVID-19: 41 Studies and 17,601 Patients.Frontiers in cardiovascular medicine · 2022Article
- Prevalence and Prognostic Importance of High Fibrosis-4 Index in COVID-19 Patients.International journal of clinical practice · 2022Article
- Tailoring glucocorticoids in patients with severe COVID-19: a narrative review.Annals of translational medicine · 2021Review
- A Pandemic within Other Pandemics. When a Multiple Infection of a Host Occurs: SARS-CoV-2, HIV andViruses · 2021Review
- Laboratory markers associated with COVID-19 progression in patients with or without comorbidity: A retrospective study.Journal of clinical laboratory analysis · 2021Article
- Temporal Associations of the SARS-CoV-2 NP Antigen and Anti-Spike Total Ig Levels with Laboratory Parameters in a Greek Cohort of Hospitalized COVID-19 Patients.Canadian respiratory journal · 2021Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
objectivesTo investigate laboratory markers for COVID-19 progression in patients with different medical conditions.
methodsWe performed a multicenter retrospective study of 836 cases in Hubei. To avoid the collinearity among the indicators, principal component analysis (PCA) followed by partial least squares discriminant analysis (PLS-DA) was performed to obtain an overview of laboratory assessments. Multivariable logistic regression analysis and multivariable Cox proportional hazards regression analysis were respectively used to explore risk factors associated with disease severity and mortality. Survival analysis was performed in patients with the most common comorbidities.
resultsLactate dehydrogenase (LDH) and prealbumin were associated with disease severity in patients with or without comorbidities, indicated by both PCA/PLS-DA and multivariable logistic regression analysis. The mortality risk was associated with age, LDH, C-reactive protein (CRP), D-dimer, and lymphopenia in patients with comorbidities. CRP was a risk factor associated with short-term mortality in patients with hypertension, but not liver diseases; additionally, D-dimer was a risk factor for death in patients with liver diseases.
conclusionsLactate dehydrogenase was a reliable predictor associated with COVID-19 severity and mortality in patients with different medical conditions. Laboratory biomarkers for mortality risk were not identical in patients with comorbidities, suggesting multiple pathophysiological mechanisms following COVID-19 infection.
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