Evidence map›Paper›PMID 33111960›Full record

ArticleActa dermato-venereologica2020

Effectiveness and Safety of Anti-interleukin-17 Therapies in Elderly Patients with Psoriasis.

Céline Phan, Nathalie Beneton, Juliette Delaunay, Ziad Reguiai, Claire Boulard, Anne-Claire Fougerousse, Elisa Cinotti, Marco Romanelli, Laure Mery-Bossard, Domitille Thomas-Beaulieu and 23 more

Open access · goldAbstract readMulticenter Study
In one paragraph

Article in Acta dermato-venereologica, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Observational
  10. Article
  11. OralDiagnostics (Basel, Switzerland) · 2021
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

33 authors at 1 institution in 1 country.

Céline PhanDepartment of Dermatology, CH Victor Dupouy, FR-95100 Argenteuil, France. E-mail: celine.phan@ch-argenteuil.fr.
Nathalie Beneton
Juliette Delaunay
Ziad Reguiai
Claire Boulard
Anne-Claire Fougerousse
Elisa Cinotti
Marco Romanelli
Laure Mery-Bossard
Domitille Thomas-Beaulieu
Josiane Parier
François Maccari
Jean-Luc Perrot
Mireille Ruer-Mulard
Marie Bastien
Edouard Begon
Mahtab Samimi
Caroline Jacobzone
Nathalie Quiles-Tsimaratos
Vincent Descamps
Maud Steff
Paul Bilan
Annie Vermersch-Langlin
Mathilde Kemula
Emmanuelle Amazan
Ingrid Kupfer-Bessaguet
Anne-Caroline Cottencin
Francesca Prignano
Bulai Livideanu
Jeremy Gottlieb
Alain Beauchet
Emmanuel Mahé
the Groupe d’Etudes Multicentriques (GEM) RESOPSO
Centre Hospitalier Victor Dupouy · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Anti-interleukin-17 agents have recently been developed for the treatment of psoriasis. This study evaluated the tolerance and effectiveness of anti-interleukin-17 agents for psoriasis in elderly patients in daily practice. A multicentre, retrospective study was performed, involving psoriatic patients aged ≥65 years who had received an anti-interleukin-17 agent, including secukinumab, ixekizumab or brodalumab. A total of 114 patients were included: 72 received secukinumab, 35 ixekizumab, and 7 brodalumab. Treatment was stopped in 32 patients (28.9%), because of relapses in 14 patients (41.2%), primary failures in 11 patients (32.4%), or adverse events in 7 patients (20.6%). The 3 most frequently reported adverse events were injection site reactions (n = 4), oral candidiasis (n = 3), and influenza-like illness (n = 3). Regarding effectiveness, 80 patients (70%) reached a Physician Global Assessment score of 0/1, 6 months after treatment initiation. In conclusion, anti-interleukin-17 therapy appears to be an effective and safe therapeutic option for psoriasis treatment in patients aged ≥ 65 years.

Indexed as

Antibodies, MonoclonalPsoriasisAgedHumansImmunotherapyRetrospective StudiesTreatment OutcomeAntibodies, Monoclonalanti-interleukin 17drug survivalelderlypsoriasissafety

Identifiers

PMID33111960
PMCPMC9309849
OpenAlexW3096784794

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.