ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2021
Powassan Virus Encephalitis Following Brief Attachment of Connecticut Deer Ticks.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 30 citations in OpenAlex.
- Lyme Disease and Other Tick-Borne Infections.Current neurology and neuroscience reports · 2026Review
- Powassan Virus in the United States: An AI-Integrative One Health Scoping Review of Ecological Drivers, Zoonotic Interactions, Symptom Profiles, and Public Health Implications.Infectious disease reports · 2026Review
- Article
- Article
- Powassan virus.Trends in microbiology · 2026Article
- Deer tick virus genotypes are perpetuated by different modes of transmission.bioRxiv : the preprint server for biology · 2026Article
- Epidemiology and risk analysis of Powassan virus infection, New York state, USA, 2013-2023.Epidemiology and infection · 2026Article
- Article
- Pathogenicity and virulence of Powassan virus.Virulence · 2025Review
- Article
- Flaviviruses-Induced Neurological Sequelae.Pathogens (Basel, Switzerland) · 2024Review
- Article
- Neurological Complications Associated With the Powassan Virus and Treatment Interventions.Cureus · 2024Review
- Powassan Virus Encephalitis after Tick Bite, Manitoba, Canada.Emerging infectious diseases · 2024Article
- Age-dependent Powassan virus lethality is linked to glial cell activation and divergent neuroinflammatory cytokine responses in a murine model.Journal of virology · 2024Article
- Powassan Virus Infections: A Systematic Review of Published Cases.Tropical medicine and infectious disease · 2023Review
- Article
- Article
- Tick species infesting humans in the United States.Ticks and tick-borne diseases · 2022Review
- Powassan Virus Encephalitis.Infectious disease clinics of North America · 2022Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundPowassan virus (POWV) is a tick-transmitted pathogen that may cause severe encephalitis; experimentally, it can be transmitted within just 15 minutes following a tick bite. The deer tick virus subtype of POWV (DTV) is transmitted by the deer tick and is the likely cause of the increase in the number of POWV cases reported in the United States. However, DTV has only been definitively documented in 6 patients by molecular analysis of the virus.
methodsTwo patients from Connecticut with encephalitis, who had a recent deer tick bite, were evaluated by the relevant serologic tests to determine if they had been infected with POWV. Evaluation also included molecular testing of an adult deer tick that had been removed from one of the patients.
resultsWe documented neuroinvasive POWV infection in 2 children from Connecticut. Based on the results of testing the tick removed from case 2, this patient was infected by DTV, representing the 7th reported case and the first documented case of DTV infection in a child. Of note, the duration of the tick bites in both cases was very short.
conclusionsWe provide the first clinical and epidemiologic evidence that POWV/DTV can be rapidly transmitted to a human host, that is, within hours of tick attachment, which is distinctive when compared to other deer tick-transmitted infections such as Lyme disease.
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