Evidence map›Paper›PMID 33111642›Full record

ReviewPain management2021

Noninvasive vagal nerve stimulation for gastroenterology pain disorders.

Andres Gottfried-Blackmore, Aida Habtezion, Linda Nguyen

Open access · greenAbstract readReview
In one paragraph

Review in Pain management, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 27 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Transcutaneous Vagal Nerve Stimulation for Gastrointestinal Disorders.Journal of translational gastroenterology · 2025
    Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Andres Gottfried-BlackmoreDivision of Gastroenterology & Hepatology, Department of Medicine, Stanford University, Stanford, CA 94305, USA.ORCID https://orcid.org/0000-0002-3563-3727
Aida HabtezionDivision of Gastroenterology & Hepatology, Department of Medicine, Stanford University, Stanford, CA 94305, USA.ORCID https://orcid.org/0000-0002-4473-006X
Linda NguyenDivision of Gastroenterology & Hepatology, Department of Medicine, Stanford University, Stanford, CA 94305, USA.
Stanford University · US

Funding

TRAINING GRANT IN ACADEMIC GASTROENTEROLOGYT32DK007056 · NIDDK · STANFORD UNIVERSITY · PI Natalie J. Torok · 1986 to 2026
$6.5M
Colleen and Robert D. Haas Generous philanthropic giftNIDDK NIH HHS 5T32DK007056-43NIDDK NIH HHS T32 DK007056
6 · The paper itself

Abstract

Abdominal pain continues to be a major challenge and unmet need in clinical practice. Normalization of bidirectional gut-brain signaling has generated much interest as a therapeutic approach to treat chronic abdominal pain. Vagal nerve stimulation (VNS) is emerging as a potential non-pharmacologic strategy for the treatment of abdominal pain. In this review paper, we will summarize the etiologies of chronic pain in gastrointestinal disorders and discuss the rational for VNS as a therapeutic approach to chronic abdominal pain, with particular emphasis in the gammaCore stimulator which allows for noninvasive VNS.

Indexed as

Central Nervous System SensitizationVagus Nerve StimulationAbdominal PainChronic PainGastrointestinal DiseasesHumanscentral sensitizationgammaCore®vagal nerve stimulationvisceral hypersensitivity

Identifiers

PMID33111642
PMCPMC7787175
OpenAlexW3095380967

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.