ArticleJournal of biomedical optics2020
Experimental validation of a spectroscopic Monte Carlo light transport simulation technique and Raman scattering depth sensing analysis in biological tissue.
Article in Journal of biomedical optics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 13 citations in OpenAlex.
- Experimental method to assess depth sensing limits of inelastic scattering measurements using spatial-offset Raman spectroscopy imaging.Journal of biomedical optics · 2025Article
- Toward fluorescence digital twins: multi-parameter experimental validation of fluorescence Monte Carlo simulations using solid phantoms.Journal of biomedical optics · 2025Article
- Development and preclinical evaluation of an endonasal Raman spectroscopy probe for transsphenoidal pituitary adenoma surgery.Journal of biomedical optics · 2025Article
- Preliminary study demonstrating cancer cells detection at the margins of whole glioblastoma specimens with Raman spectroscopy imaging.Scientific reports · 2025Article
- In situ brain tumor detection using a Raman spectroscopy system-results of a multicenter study.Scientific reports · 2024Article
- Macroscopic inelastic scattering imaging using a hyperspectral line-scanning system identifies invasive breast cancer in lumpectomy and mastectomy specimens.Journal of biomedical optics · 2024Article
- Subsecond lung cancer detection within a heterogeneous background of normal and benign tissue using single-point Raman spectroscopy.Journal of biomedical optics · 2023Article
- Preclinical evaluation of Raman spectroscopy for pedicular screw insertion surgical guidance in a porcine spine model.Journal of biomedical optics · 2023Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
significanceRaman spectroscopy (RS) applied to surgical guidance is attracting attention among scientists in biomedical optics. Offering a computational platform for studying depth-resolved RS and probing molecular specificity of different tissue layers is of crucial importance to increase the precision of these techniques and facilitate their clinical adoption.
aimThe aim of this work was to present a rigorous analysis of inelastic scattering depth sampling and elucidate the relationship between sensing depth of the Raman effect and optical properties of the tissue under interrogation. APPROACH: A new Monte Carlo (MC) package was developed to simulate absorption, fluorescence, elastic, and inelastic scattering of light in tissue. The validity of the MC algorithm was demonstrated by comparison with experimental Raman spectra in phantoms of known optical properties using nylon and polydimethylsiloxane as Raman-active compounds. A series of MC simulations were performed to study the effects of optical properties on Raman sensing depth for an imaging geometry consistent with single-point detection using a handheld fiber optics probe system.
resultsThe MC code was used to estimate the Raman sensing depth of a handheld fiber optics system. For absorption and reduced scattering coefficients of 0.001 and 1 mm - 1, the sensing depth varied from 105 to 225 μm for a range of Raman probabilities from 10 - 6 to 10 - 3. Further, for a realistic Raman probability of 10 - 6, the sensing depth ranged between 10 and 600 μm for the range of absorption coefficients 0.001 to 1.4 mm - 1 and reduced scattering coefficients of 0.5 to 30 mm - 1.
conclusionsA spectroscopic MC light transport simulation platform was developed and validated against experimental measurements in tissue phantoms and used to predict depth sensing in tissue. It is hoped that the current package and reported results provide the research community with an effective simulating tool to improve the development of clinical applications of RS.
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