ArticleEuropean archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry2021
Regenerative endodontics: a promising tool to promote periapical healing and root maturation of necrotic immature permanent molars with apical periodontitis using platelet-rich fibrin (PRF).
Article in European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- Association of Apical Maturity With Clinical and Biological Outcomes After Regenerative Endodontic Procedures: A Systematic Review and Meta-Analysis.International dental journal · 2026Pooled it
- Tissue Characteristics in Endodontic Regeneration: A Systematic Review.International journal of molecular sciences · 2022Pooled it
- Trial
- Favorable Eruption Despite External Replacement Root Resorption in Delayed Replantation of Avulsed Teeth Treated With Regenerative Endodontics-An Observational Study.Dental traumatology : official publication of International Association for Dental Traumatology · 2026Observational
- Article
- Outcome of Guided Pulpal Regeneration in Immature Molar Teeth with Chronic Apical Abscess: A Case Report and Mini-Review.Frontiers in dentistry · 2026Article
- Regenerative Endodontic Therapy of an Immature Permanent Molar With Necrotic Pulp and Symptomatic Apical Periodontitis Using Platelet-Rich Fibrin: A 52-Month Follow-Up Case Report.Case reports in dentistry · 2026Article
- Assessment of regenerative endodontic procedures using platelet-rich fibrin in immature necrotic teeth.Bioinformation · 2026Article
- Regenerative endodontic therapy assisted by a concentrated growth factor scaffold for bilateral symmetrical dens evaginatus fractures in permanent teeth: a case report.American journal of translational research · 2025Article
- Pulp regeneration treatment using different bioactive materials in permanent teeth of pediatric subjects.Journal of conservative dentistry and endodontics · 2024Review
- The effect of injectable platelet-rich fibrin and platelet-rich fibrin in regenerative endodontics: a comparative in vitro study.Journal of applied oral science : revista FOB · 2024Article
- The current regenerative medicine approaches of craniofacial diseases: A narrative review.Frontiers in cell and developmental biology · 2023Review
- Biomaterial scaffolds for clinical procedures in endodontic regeneration.Bioactive materials · 2022Article
- Radiographic differences observed following apexification vs revascularization in necrotic immature molars and incisors: a follow-up study of 18 teeth.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2022Article
- Platelet-Therapeutics to Improve Tissue Regeneration and Wound Healing-Physiological Background and Methods of Preparation.Biomedicines · 2021Review
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeCurrently, mineral trioxide aggregate (MTA) apexification is recommended as the preferred treatment for permanent anterior immature necrotic teeth. Apexification treatment does not enable further development and maturation of the teeth, resulting in short roots with thin root canal walls, that often are prone to cervical fractures. This study presents the regenerative endodontic procedure (REP) as an alternative treatment for immature necrotic molars with apical periodontitis or a chronic apical abscess. REP enables periapical healing as well as root lengthening and widening of the dentinal root canal walls. CASE SERIES
resultsSix immature first molars teeth (five mandibular, one maxillary) with apical periodontitis or chronic apical abscess were treated with REP. Patients underwent periodic follow-up visits every 3 months the first year and twice a year thereafter. The final clinical examination revealed no symptoms, no gingival pockets, and no sensitivity to percussion. Cold sensitivity tests were negative. Radiographs revealed full periapical healing in all the treated molars, remarkable root lengthening, and dentinal wall thickening.
conclusionREP with PRF is feasible and may have some advantages over MTA apexification since it facilitates root elongation, dentinal thickening of the root canals walls, and narrowing of the apical foramen.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.