Evidence map›Paper›PMID 33111161›Full record

ArticleInternational urology and nephrology2021

The effect of anemia on the efficacy and safety of treating chronic hepatitis C infection with direct-acting antivirals in patients with chronic kidney disease.

Ahmed Yahia Elmowafy, Mohamed Hamed Abbas, Ahmed Abdelfattah Denewar, Mohamed Elsayed Mashaly, Gamal Shiha, Salwa Mahmoud El Wasif, Lionel Rostaing, Mohamed Adel Bakr

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Article in International urology and nephrology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Ahmed Yahia ElmowafyUrology and Nephrology Center, Mansoura University, Mansoura, Egypt.
Mohamed Hamed AbbasUrology and Nephrology Center, Mansoura University, Mansoura, Egypt.
Ahmed Abdelfattah DenewarUrology and Nephrology Center, Mansoura University, Mansoura, Egypt.
Mohamed Elsayed MashalyUrology and Nephrology Center, Mansoura University, Mansoura, Egypt.
Gamal ShihaEgyptian Liver Research Institute and Hospital, Mansoura, Egypt.
Salwa Mahmoud El WasifUrology and Nephrology Center, Mansoura University, Mansoura, Egypt.
Lionel Rostaing *Université Grenoble Alpes, Grenoble, France. lrostaing@chu-grenoble.fr.ORCID http://orcid.org/0000-0002-5130-7286
Mohamed Adel Bakr *Urology and Nephrology Center, Mansoura University, Mansoura, Egypt.
Mansoura University · EGCentre Hospitalier Universitaire de Grenoble · FRMansoura University Hospital · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimChronic hepatitis-C infection is a great health burden in Egypt. The effect of anemia on the efficacy and safety of direct-acting anti-viral (DAA) therapies for those with chronic-kidney disease (CKD) has not been evaluated. PATIENTS/

methodsThis single-center retrospective study included 235 renal patients: i.e., 70-CKD patients not on hemodialysis (42 with anemia, 28 without); 40 hemodialysis patients (16 anemic; 24 non-anemic), and 125 kidney-transplant (KTx) recipients (40 anemic; 85 non-anemic). Anemia was defined by a hemoglobin level < 10.5 g/dL. Hemodialysis patients received ritonavir-boosted paritaprevir/ombitasvir. KTx patients received sofosbuvir/daclatasvir. CKD patients with eGFR > 30 mL/min/1.73 m

resultsMean age of CKDs was 49.1 years, 43.2 years for HDs, and 45.2 years for KTx patients. Most were male; body-mass index was ~ 23.8. Anemia did not affect the efficacy of DAAs in hemodialysis, CKD, or KTx patients. Most patients achieved a rapid virologic response (RVR), and a 12- and 24-week sustained viral response. Worsening of anemia among the non-anemic group was mostly related to ribavirin therapy in hemodialysis patients (11/16 patients). Acute kidney injury in CKDs occurred more frequently within the anemic group (59.5%) compared to the non-anemic group (32.1%). For KTx, graft impairment was more common among the anemic group (7/40) compared to the non-anemic group (2/85).

conclusionHemoglobin levels of < 10.5 g/dL prior to DAA treatment did not affect the virological response in renal patients but was associated with increased serum creatinine among KTx and those with CKD.

Indexed as

AdultAnemiaAntiviral AgentsCohort StudiesFemaleHepatitis C, ChronicHumansMaleMiddle AgedRenal Insufficiency, ChronicRetrospective StudiesTreatment OutcomeAntiviral AgentsAnemiaChronic kidney diseaseDAA therapyDaclatasvirHCV infectionHemodialysisKidney transplantationSofosbuvir

Identifiers

PMID33111161
OpenAlexW3097320771

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.