Evidence map›Paper›PMID 33110978›Full record

ArticleACS omega2020

Tandem Mass Tag-Based Serum Proteome Profiling for Biomarker Discovery in Young Duchenne Muscular Dystrophy Boys.

Tchilabalo D Alayi, Shefa M Tawalbeh, Michael Ogundele, Holly R Smith, Alison M Samsel, Marissa L Barbieri, Yetrib Hathout

Open access · goldAbstract read
In one paragraph

Article in ACS omega, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 15 citations in OpenAlex.

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  8. Serum protein biomarker signature of Duchenne muscular dystrophy.European journal of translational myology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Tchilabalo D AlayiDepartment of Pharmaceutical Science, School of Pharmacy and Pharmaceutical Sciences, Binghamton University-SUNY, Johnson City, New York 13790, United States.
Shefa M TawalbehDepartment of Pharmaceutical Science, School of Pharmacy and Pharmaceutical Sciences, Binghamton University-SUNY, Johnson City, New York 13790, United States.
Michael OgundeleDepartment of Pharmaceutical Science, School of Pharmacy and Pharmaceutical Sciences, Binghamton University-SUNY, Johnson City, New York 13790, United States.
Holly R SmithDepartment of Pharmaceutical Science, School of Pharmacy and Pharmaceutical Sciences, Binghamton University-SUNY, Johnson City, New York 13790, United States.
Alison M SamselDepartment of Pharmaceutical Science, School of Pharmacy and Pharmaceutical Sciences, Binghamton University-SUNY, Johnson City, New York 13790, United States.
Marissa L BarbieriDepartment of Pharmaceutical Science, School of Pharmacy and Pharmaceutical Sciences, Binghamton University-SUNY, Johnson City, New York 13790, United States.
Yetrib HathoutDepartment of Pharmaceutical Science, School of Pharmacy and Pharmaceutical Sciences, Binghamton University-SUNY, Johnson City, New York 13790, United States.
Binghamton University · US

Funding

Dissociation of efficacy from side effects of anti-inflammatory therapies in Duchenne muscular dystrophyP50HD090254 · NICHD · CHILDREN'S RESEARCH INSTITUTE · PI VAN DEN ANKER, JOHANNES NICOLAAS · 2019 to 2020
$1.6M
Clinically Meaningful Outcomes for Duchenne Muscular Dystrophy Therapeutic TrialsR01AR061875 · NIAMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI MCDONALD, CRAIG M. · 2011 to 2014
$1.3M
NIAMS NIH HHS R01 AR061875NICHD NIH HHS P50 HD090254
6 · The paper itself

Abstract

Blood-accessible molecular biomarkers are becoming highly attractive tools to assess disease progression and response to therapies in Duchenne muscular dystrophy (DMD) especially in very young patients for whom other outcome measures remain subjective and challenging. In this study, we have standardized a highly specific and reproducible multiplexing mass spectrometry method using the tandem mass tag (TMT) strategy in combination with depletion of abundant proteins from serum and high-pH reversed-phase peptide fractionation. Differential proteome profiling of 4 year-old DMD boys (

Identifiers

PMID33110978
PMCPMC7581259
OpenAlexW3092426191

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.