ReviewNPJ microgravity2020
COVID-19-The largest isolation study in history: the value of shared learnings from spaceflight analogs.
Review in NPJ microgravity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04856410 (Temporal Nature of Cognitive and Visuospatial Brain Domain Changes During Long-Duration Low-Earth Orbit Missions), which is not on this map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Temporal Nature of Cognitive and Visuospatial Brain Domain Changes During Long-Duration Low-Earth Orbit Missions (Spatial Cognition)
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Human social isolation and stress: a systematic review of different contexts and recommendations for future studies.Trends in psychiatry and psychotherapy · 2024Pooled it
- The physiology of survival: Space.Experimental physiology · 2026Article
- Value dynamics and interpersonal tension among astronauts during International Space Station missions.PloS one · 2026Article
- The utility of animal models to inform the next generation of human space exploration.NPJ microgravity · 2025Review
- Nursing students in isolation during the COVID-19 pandemic: A phenomenological study.Health SA = SA Gesondheid · 2025Article
- Paving the way to better understand the effects of prolonged spaceflight on operational performance and its neural bases.NPJ microgravity · 2023Review
- Social Isolation: A Narrative Review on the Dangerous Liaison between the Autonomic Nervous System and Inflammation.Life (Basel, Switzerland) · 2023Review
- Off-World Mental Health: Considerations for the Design of Well-being-Supportive Technologies for Deep Space Exploration.JMIR formative research · 2023Article
- Countermeasures for Maintaining Cardiovascular Health in Space Missions.Current cardiology reviews · 2023Article
- An eight country cross-sectional study of the psychosocial effects of COVID-19 induced quarantine and/or isolation during the pandemic.Scientific reports · 2022Article
- ANN-Based traffic volume prediction models in response to COVID-19 imposed measures.Sustainable cities and society · 2022Article
- Virtual Reality "exergames": A promising countermeasure to improve motivation and restorative effects during long duration spaceflight missions.Frontiers in physiology · 2022Article
- Future research directions to identify risks and mitigation strategies for neurostructural, ocular, and behavioral changes induced by human spaceflight: A NASA-ESA expert group consensus report.Frontiers in neural circuits · 2022Article
- The Cardiovascular System in Space: Focus on In Vivo and In Vitro Studies.Biomedicines · 2021Review
- Article
- Increased gaze cueing of attention during COVID-19 lockdown.iScience · 2021Article
- The Impact of the COVID-19 Pandemic on Mental Disorders. A Critical Review.International journal of environmental research and public health · 2021Review
- Brains in space: the importance of understanding the impact of long-duration spaceflight on spatial cognition and its neural circuitry.Cognitive processing · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The world is currently experiencing the largest isolation experiment in history. In an attempt to slow down the spread of the COVID-19 pandemic numerous countries across the world have been shutting down economies, education, and public life. Governments have mandated strict regulations of quarantine and social distancing in an unprecedented manner. The effects of these measures on brain, behavior, neuro-humoral and immunological responses in humans are largely unknown. Life science research for space exploration has a long history in using high-fidelity spaceflight analogs to better understand the effect of prolonged isolation and confinement on genes, molecules, cells, neural circuits, and physiological systems to behavior. We here propose to leverage the extensive experience and data from these studies and build a bridge between spaceflight research and clinical settings to foster transdisciplinary approaches to characterize the neurobehavioral effects on the immune system and vice versa. These approaches are expected to develop innovative and efficient health screening tools, diagnostic systems, and treatments to mitigate health risks associated with isolation and confinement on Earth and during future exploratory spaceflight missions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.