ReviewJournal of family medicine and primary care2020
External apical root resorption in orthodontic patients: molecular and genetic basis.
Review in Journal of family medicine and primary care, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06198322 (Assessment of the Effects of Platelet-rich Fibrin and Vitamin Dꝫ Injections on Root Resorption), which is not on this map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Assessment of the Effects of Platelet-rich Fibrin and Vitamin Dꝫ Injections on Root Resorption: A Randomized Controlled Clinical Trial
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Orthodontically induced external apical root resorption considerations of root-filled teeth vs vital pulp teeth: a systematic review and meta-analysis.BMC oral health · 2023Pooled it
- The Impact of the Orthodontic Forces on the Internal Resorptive Process for Intact Periodontium: A Finite Element Analysis.Journal of clinical medicine · 2026Article
- Orthodontically Induced External Root Resorption: A Finite Element Analysis.Journal of clinical medicine · 2026Article
- Investigation of genetic polymorphisms associated with severe root resorption in orthodontic surgery patients.Brazilian dental journal · 2026Article
- Comparative evaluation of ChatGPT and Gemini in detecting external apical root resorption on panoramic radiographs of orthodontic patients : Artificial intelligence performance in detecting root resorption.Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie · 2025Article
- Effect of 3D-printing assisted micro-osteoperforations on the rate of canine retraction: a clinical investigation.BMC oral health · 2025Article
- Three-dimensional partitioning and quantification of orthodontic root resorption via automatic root extraction from cone-beam computed tomography.BMC oral health · 2025Article
- Orthodontically induced root resorption in endodontically treated and vital teeth: a cone beam computer tomographic study.Progress in orthodontics · 2025Article
- Investigating the Role of Genetic Polymorphisms in External Apical Root Resorption Among Orthodontic Patients: Implications for Treatment Outcomes-A Literature Review.Reports (MDPI) · 2025Review
- Panoramic evaluation of external root resorption in mandibular molars during orthodontic treatment: a comparison between root-filled and vital teeth treated with fixed appliances or clear aligners.BMC oral health · 2024Article
- Genetic polymorphisms linked to extreme postorthodontic external apical root resorption in Koreans.Progress in orthodontics · 2024Article
- External apical root resorption in African American orthodontic patients.European journal of orthodontics · 2024Article
- Effect of genetic factors on root resorption after orthodontic treatment: A systematic review.Bioinformation · 2024Article
- Genetic and other factors contributing to external apical root resorption in orthodontic patients.Orthodontics & craniofacial research · 2023Article
- Research Advances on Stem Cell-Derived Extracellular Vesicles Promoting the Reconstruction of Alveolar Bone through RANKL/RANK/OPG Pathway.Journal of functional biomaterials · 2023Review
- Antimicrobial Activity of Various Disinfectants to Clean Thermoplastic Polymeric Appliances in Orthodontics.Polymers · 2022Review
- Role of chaperone-assisted selective autophagy (CASA) in mechanical stress protection of periodontal ligament cells.Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie · 2022Article
- The effect of micro-osteoperforations on the rate of orthodontic tooth movement in animal model: A systematic review and meta-analysis.Journal of oral biology and craniofacial researchReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
External apical root resorption is one of the most deleterious complications after orthodontic treatment. Studies to explain the causal relationship between orthodontic tooth movement and external apical root resorption have been inconclusive till date. Individual variations in external apical root resorption sometimes overshadow the treatment related factors which indicate genetic predisposition and/or multifactorial etiology. Mechanism of root resorption is not completely understood. Inflammatory root resorption induced by orthodontic treatment is a part of process of elimination of hyaline zone. An imbalance between bone resorption and deposition may contribute to root resorption by the cementoclasts/osteoclasts. This narrative review article explains the molecular pathway involved in external apical root resorption and also role of various genes involved at different level. It also reviews the literature published during the past 20 years concerning the association studies linking EARR to genetic polymorphisms. This literature review provides an insight into genetic predisposition of external apical root resorption that can be used in orthodontic practice to enable 'high-risk' subjects to be identified on the basis of their genetic information before orthodontic treatment is initiated.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.