ArticleMultiple sclerosis journal - experimental, translational and clinical
Familial aggregation of multiple sclerosis: Results from the national registry of the disease in Saudi Arabia.
Article in Multiple sclerosis journal - experimental, translational and clinical. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- The global prevalence of familial multiple sclerosis: an updated systematic review and meta-analysis.BMC neurology · 2021Pooled it
- Physicians' Knowledge and Practice Regarding Multiple Sclerosis (MS) in Saudi Arabia: A Cross-Sectional Study.Journal of multidisciplinary healthcare · 2026Article
- Evaluating the Impact of Teriflunomide and Dimethyl Fumarate on Quality of Life in Relapsing-remitting Multiple Sclerosis: Insights from Eastern Saudi Arabia.Annals of African medicine · 2025Article
- Exome sequencing reveals low-frequency and rare variant contributions to multiple sclerosis susceptibility in Turkish families.Scientific reports · 2025Article
- The role of parental consanguinity and familial aggregation in development of multiple sclerosis: a case-control study.European journal of medical research · 2024Article
- Consanguineous marriage among familial multiple sclerosis subjects: A national registry-based study.Heliyon · 2024Article
- Prophylactic administration of PEPITEM in experimental autoimmune encephalomyelitis delays disease onset, inhibits leukocyte infiltration, and alleviates severity.International journal of clinical and experimental pathology · 2024Article
- Multiple Sclerosis-A Demyelinating Disorder and Its Dental Considerations-A Literature Review with Own Case Report.Brain sciences · 2023Review
- Demographic and Clinical Characteristics of Familial and Sporadic Multiple Sclerosis Patients.International journal of preventive medicine · 2023Article
- Unmet Needs and Treatment of Relapsing-Remitting Multiple Sclerosis in Saudi Arabia: Focus on the Role of Ofatumumab.Neurology and therapy · 2022Article
- Clinical Profile and the Extent of Disability in Multiple Sclerosis Patients in Madinah, Saudi Arabia.Cureus · 2022Article
- Epidemiology of familial multiple sclerosis in Iran: a national registry-based study.BMC neurology · 2022Article
- Prevalence of Pediatric Onset Multiple Sclerosis in Saudi Arabia.Multiple sclerosis international · 2021Article
- Achievement of No Evidence of Disease Activity-3 with Oral Disease-Modifying Treatment in Patients with Relapsing-Remitting Multiple Sclerosis.Saudi journal of medicine & medical sciencesArticle
- Anticipated Stigma among Patients with Multiple Sclerosis in Saudi Arabia.Saudi journal of medicine & medical sciencesArticle
Corrections and comments
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Authors and funding
17 authors at 7 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMultiple Sclerosis (MS) is a chronic CNS inflammatory disease commonly affecting young adults. Both genetics and environmental factors have been reported to have a role in pathophysiology of the disease.
objectiveThis article aims to report familial nature and aspects of MS in Saudi Arabia.
methodThe study utilized data collected by the National Saudi MS Registry between 2015 and 2018; especially data relevant to the familial history of MS. SPSS 22 was used for all analysis and reporting. Statistical significance was set at p-value < 0.05.
resultsThe registry included 20 hospitals and a total of 2516 patients from the different regions of Saudi Arabia with median age 32.00 (Range: 11-63) and 66.5% being female. About 12.8% of all registered patients reported a family history of MS (95%CI: 11.2-13.9). Reported parental consanguinity was significantly higher among patients with family history (FMS) (56.3%) compared to non-FMS patients (27.9%). 42.53% of FMS patients reported having siblings affected with MS (95%CI: 37.01-48.21), with more female siblings affected than males (63.4% vs 36.6% respectively).
conclusionOur Findings suggested that FMS was less prevalent than what was reported previously; however, parental consanguinity was significantly more prevalent among FMS patients than non-FMS. Our findings were in line with those reported in recent studies in the region, but lower than those reported by western countries indicating that increasing prevalence of MS in Saudi Arabia could be multifactorial and other environmental factors should be considered for understanding this recent rise in the prevalence of MS in Saudi Arabia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.