Evidence map›Paper›PMID 33110612›Full record

ArticleTropical diseases, travel medicine and vaccines2020

The dangers of mass drug administration of albendazole in Nepal, a Neurocysticercosis-endemic region.

Gaurav Nepal, Ghanshyam Kharel, Yow Ka Shing, Rajeev Ojha, Sujan Jamarkattel, Jayant Kumar Yadav, Himani Vyas, Dhiraj Poudyal, Ranjit Sah

Open access · goldAbstract read
In one paragraph

Article in Tropical diseases, travel medicine and vaccines, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 83% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 4 countries.

Gaurav NepalMaharajgunj Medical Campus, Tribhuvan University Institute of Medicine, Maharajgunj Rd, Kathmandu, 44600 Nepal.ORCID 0000-0001-5054-2711
Ghanshyam KharelDepartment of Neurology, National Academy of Medical Sciences, Mahaboudha, Kathmandu, 44600 Nepal.
Yow Ka ShingDepartment of Internal Medicine, National University Hospital, 5 Lower Kent Ridge Rd, Singapore, 119074 Singapore.
Rajeev OjhaDepartment of Neurology, Maharajgunj Medical Campus, Tribhuvan University Institute of Medicine, Maharajgunj Rd, Kathmandu, 44600 Nepal.
Sujan JamarkattelDepartment of Infectious Diseases, Tufts Medical Centre, 800 Washington St, Boston, MA 02111 USA.
Jayant Kumar YadavMaharajgunj Medical Campus, Tribhuvan University Institute of Medicine, Maharajgunj Rd, Kathmandu, 44600 Nepal.
Himani VyasAll India Institute of Medical Sciences, Sri Aurobindo Marg, Ansari Nagar, New Delhi, Delhi, 110029 India.
Dhiraj PoudyalMaharajgunj Medical Campus, Tribhuvan University Institute of Medicine, Maharajgunj Rd, Kathmandu, 44600 Nepal.
Ranjit SahDepartment of Microbiology, Maharajgunj Medical Campus, Tribhuvan University Institute of Medicine, Maharajgunj Rd, Kathmandu, 44600 Nepal.
Tribhuvan University Teaching Hospital · NPAll India Institute of Medical Sciences · INNational Academy of Medical Sciences · NPNational University Hospital · SGTufts Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The majority of cases of Neurocysticercosis (NCC) are asymptomatic. Injudicious use of antihelmintics like albendazole (ALB) can cause cyst degeneration and perilesional inflammation, thus rendering asymptomatic individuals symptomatic with seizures, headache, vascular events, or cerebral edema. Mass drug administration (MDA) using ALB is a very common practice in developing countries like Nepal to contain transmission of soil-transmitted helminths (STH) and lymphatic filariasis (LF). Although the benefits of ALB-based MDA in the general population cannot be undermined, there can be severe consequences in certain groups, especially those with latent NCC. In this commentary, we discuss the effect it may have on such patients, and suggest potential solutions.

Indexed as

AlbendazoleLymphatic filariasisNeurocysticercosisSoil-transmitted helminths

Identifiers

PMID33110612
PMCPMC7585209
OpenAlexW3094003328

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.