Evidence map›Paper›PMID 33110456›Full record

ArticleDisease markers2020

Identification of a Set of Genes Improving Survival Prediction in Kidney Renal Clear Cell Carcinoma through Integrative Reanalysis of Transcriptomic Data.

Banlai Ruan, Xianzhen Feng, Xueyi Chen, Zhiwei Dong, Qi Wang, Kai Xu, Jinping Tian, Jie Liu, Ziyin Chen, Wenzhen Shi and 3 more

Open access · hybridAbstract read
In one paragraph

Article in Disease markers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Review
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  8. DecreasedFrontiers in molecular biosciences · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Banlai RuanMedical Research Center, Xi'an No. 3 Hospital, the Affiliated Hospital of Northwest University, Xi'an, 710016 Shaanxi Province, China.ORCID https://orcid.org/0000-0002-7551-3156
Xianzhen FengDepartment of Obstetrics and Gynecology, The Third People's Hospital of Linyi, Linyi, 276000 Shandong Province, China.ORCID https://orcid.org/0000-0002-9956-8637
Xueyi ChenMedical Research Center, Xi'an No. 3 Hospital, the Affiliated Hospital of Northwest University, Xi'an, 710016 Shaanxi Province, China.ORCID https://orcid.org/0000-0002-9535-4543
Zhiwei DongHubei Yicanhealth Co., Ltd., Wuhan, 430070 Hubei Province, China.ORCID https://orcid.org/0000-0003-0600-8954
Qi WangDepartment of Oncology, Affiliated Hospital of Qingdao University, Qingdao, 266000 Shandong Province, China.ORCID https://orcid.org/0000-0001-7155-8878
Kai XuHubei Yicanhealth Co., Ltd., Wuhan, 430070 Hubei Province, China.ORCID https://orcid.org/0000-0003-4163-2904
Jinping TianHubei Yicanhealth Co., Ltd., Wuhan, 430070 Hubei Province, China.ORCID https://orcid.org/0000-0002-4186-0985
Jie LiuMedical Research Center, Xi'an No. 3 Hospital, the Affiliated Hospital of Northwest University, Xi'an, 710016 Shaanxi Province, China.ORCID https://orcid.org/0000-0003-1173-6809
Ziyin ChenHubei Yicanhealth Co., Ltd., Wuhan, 430070 Hubei Province, China.ORCID https://orcid.org/0000-0003-0335-1028
Wenzhen ShiMedical Research Center, Xi'an No. 3 Hospital, the Affiliated Hospital of Northwest University, Xi'an, 710016 Shaanxi Province, China.ORCID https://orcid.org/0000-0002-8055-1114
Man WangHubei Yicanhealth Co., Ltd., Wuhan, 430070 Hubei Province, China.ORCID https://orcid.org/0000-0002-7364-7994
Lu QianMedical Research Center, Xi'an No. 3 Hospital, the Affiliated Hospital of Northwest University, Xi'an, 710016 Shaanxi Province, China.ORCID https://orcid.org/0000-0003-2388-0357
Qianshan DingMedical Research Center, Xi'an No. 3 Hospital, the Affiliated Hospital of Northwest University, Xi'an, 710016 Shaanxi Province, China.ORCID https://orcid.org/0000-0002-9989-6876
Northwest University · CNLinyi People's Hospital · CNQingdao University · CNWuhan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWith an enormous amount of research concerning kidney cancer being conducted, various treatments have been applied to its cure. However, high recurrence and metastasis rates continue to pose a threat to the survival of patients with kidney renal clear cell carcinoma (KIRC).

methodsData from The Cancer Genome Atlas were downloaded, and a series of analyses were performed, including differential analysis, Cox analysis, weighted gene coexpression network analysis, least absolute shrinkage and selection operator analysis, multivariate Cox analysis, survival analysis, and receiver operating characteristic curve and functional enrichment analysis.

resultsA total of 5,777 differentially expressed genes were identified from the differential analysis. The Cox analysis showed 1,853 significant genes (

conclusionThe gene expression model consisting of CDKL2, LRFN1, STAT2, and SOWAHB is a promising tool for predicting the prognosis of patients with KIRC. The results of this study may provide insights into the diagnosis and treatment of KIRC.

Indexed as

AgedBiomarkers, TumorCarcinoma, Renal CellComputational BiologyCyclin-Dependent KinasesFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticGene Regulatory NetworksHumansKidney NeoplasmsMaleMembrane GlycoproteinsMiddle AgedNerve Tissue ProteinsPrognosisBiomarkers, TumorCDKL2 protein, humanCyclin-Dependent KinasesLRFN2 protein, humanMembrane GlycoproteinsNerve Tissue ProteinsSTAT2 protein, humanSTAT2 Transcription Factor

Identifiers

PMID33110456
PMCPMC7578724
OpenAlexW3093201591

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.