ArticleScientific reports2020
Disrupted white matter integrity and network connectivity are related to poor motor performance.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 27 citations in OpenAlex.
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- Behavioral and psychophysical characterization of proprioceptive impairment in healthy aging: a hyper-illusory experience of movement.npj aging · 2026Article
- Linking inflammatory and structural neuroimaging biomarkers in treatment-resistant depression: Current evidence and emerging hypotheses.Neuroscience applied · 2026Review
- White Matter Microstructural Injury in Patients With Acute Single Subcortical Infarction: A Preliminary Tract-Based Spatial Statistics With Atlas-Based Analysis.Neural plasticity · 2026Article
- Dose-dependent white matter changes associated with repetitive head impacts in former American football players.Brain communications · 2026Article
- Role of glia in delirium: proposed mechanisms and translational implications.Molecular psychiatry · 2025Review
- Gait Characteristics and Neuroanatomical Alterations in Obstructive Sleep Apnea-Hypopnea Syndrome.Nature and science of sleep · 2025Article
- Leukoaraiosis does not impact motor outcomes in Parkinson's patients post deep brain stimulation.Clinical parkinsonism & related disorders · 2025Article
- Associations of Neurological Biomarkers in Serum With Gait Measures: The Cardiovascular Health Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Novel computerized neurocognitive test battery is sensitive to cancer-related cognitive deficits in survivors.Journal of cancer survivorship : research and practice · 2024Article
- Stride length and cerebellar regulation: Key features of early gait disorder in cerebral small vessel disease.CNS neuroscience & therapeutics · 2024Article
- Bridging Reduced Grip Strength and Altered Executive Function: Specific Brain White Matter Structural Changes in Patients with Alzheimer's Disease.Clinical interventions in aging · 2024Article
- Article
- Remote, Computerised Cognitive Assessment for Breast Cancer- and Treatment-Related Cognitive Dysfunction: Psychometric Characteristics of the Cogsuite Neurocognitive Battery.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2023Article
- Perceptual Integration Compensates for Attention Deficit in Elderly during Repetitive Auditory-Based Sensorimotor Task.Sensors (Basel, Switzerland) · 2023Article
- Oxymatrine ameliorates white matter injury by modulating gut microbiota after intracerebral hemorrhage in mice.CNS neuroscience & therapeutics · 2023Article
- Aging increases proprioceptive error for a broad range of movement speed and distance estimates in the upper limb.Frontiers in human neuroscience · 2023Article
- Decomposing MRI phenotypic heterogeneity in epilepsy: a step towards personalized classification.Brain : a journal of neurology · 2022Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Motor impairment is common in the elderly population. Disrupted white matter tracts and the resultant loss of connectivity between cortical regions play an essential role in motor control. Using diffusion tensor imaging (DTI), we investigated the effect of white matter microstructure on upper-extremity and lower-extremity motor function in a community-based sample. A total of 766 participants (57.3 ± 9.2 years) completed the assessment of motor performance, including 3-m walking speed, 5-repeat chair-stand time, 10-repeat hand pronation-supination time, and 10-repeat finger-tapping time. Fractional anisotropy (FA), mean diffusivity (MD), and structural network connectivity parameters were calculated based on DTI. Lower FA and higher MD were associated with poor performance in walking, chair-stand, hand pronation-supination, and finger-tapping tests, independent of the presence of lacunes, white matter hyperintensities volume, and brain atrophy. Reduced network density, network strength, and global efficiency related to slower hand pronation-supination and finger-tapping, but not related to walking speed and chair-stand time. Disrupted white matter integrity and reduced cerebral network connectivity were associated with poor motor performance. Diffusion-based methods provide a more in-depth insight into the neural basis of motor dysfunction.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.