Evidence map›Paper›PMID 33110146›Full record

ArticleScientific reports2020

Akt isoform-specific effects on thyroid cancer development and progression in a murine thyroid cancer model.

Motoyasu Saji, Caroline S Kim, Chaojie Wang, Xiaoli Zhang, Tilak Khanal, Kevin Coombes, Krista La Perle, Sheue-Yann Cheng, Philip N Tsichlis, Matthew D Ringel

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. The Year in Basic Thyroid Cancer Research.Thyroid : official journal of the American Thyroid Association · 2022
    Article
  6. Novel Inhibitor-Based Therapies for Thyroid Cancer-An Update.International journal of molecular sciences · 2021
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Motoyasu SajiDivision of Endocrinology, Diabetes, and Metabolism, The Ohio State University College of Medicine and Arthur G. James Comprehensive Cancer Center, 506 Biomedical Research Tower, 560 West 12th Avenue, Columbus, OH, 43210, USA.
Caroline S KimDivision of Endocrinology, University of Pennsylvania, Philadelphia, PA, USA.
Chaojie WangDivision of Endocrinology, Diabetes, and Metabolism, The Ohio State University College of Medicine and Arthur G. James Comprehensive Cancer Center, 506 Biomedical Research Tower, 560 West 12th Avenue, Columbus, OH, 43210, USA.
Xiaoli ZhangCenter for Biostatistics, The Ohio State University College of Medicine and Arthur G. James Comprehensive Cancer Center, Columbus, OH, USA.
Tilak KhanalDivision of Endocrinology, Diabetes, and Metabolism, The Ohio State University College of Medicine and Arthur G. James Comprehensive Cancer Center, 506 Biomedical Research Tower, 560 West 12th Avenue, Columbus, OH, 43210, USA.
Kevin CoombesCenter for Biostatistics, The Ohio State University College of Medicine and Arthur G. James Comprehensive Cancer Center, Columbus, OH, USA.
Krista La PerleCollege of Veterinary Medicine, The Ohio State University, Columbus, OH, USA.
Sheue-Yann ChengNational Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Philip N TsichlisDepartment of Cancer Biology and Genetics, The Ohio State University College of Medicine and Arthur G. James Comprehensive Cancer Center, Columbus, OH, USA.
Matthew D RingelDivision of Endocrinology, Diabetes, and Metabolism, The Ohio State University College of Medicine and Arthur G. James Comprehensive Cancer Center, 506 Biomedical Research Tower, 560 West 12th Avenue, Columbus, OH, 43210, USA. matthew.ringel@osumc.edu.
The Ohio State University · USThe Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute · USNational Cancer Institute · USUniversity of Pennsylvania · US

Funding

Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Tasleem J Padamsee · 1985 to 2026
$132.3M
Selective Modulation of Thyroidal RadioiodineP01CA124570 · NCI · OHIO STATE UNIVERSITY · PI RINGEL, MATTHEW D · 2008 to 2017
$23.4M
Role of p21-activated kinases in thyroid cancerR01CA227847 · NCI · OHIO STATE UNIVERSITY · PI RINGEL, MATTHEW D · 2018 to 2022
$1.9M
Akt Intracellular Localization in Thyroid CancerR01CA102572 · NCI · OHIO STATE UNIVERSITY · PI RINGEL, MATTHEW D · 2005 to 2009
$1.3M
NCI NIH HHS P30 CA016058NCI NIH HHS R01 CA102572NCI NIH HHS R01 CA227847NIH HHS P01CA124570
6 · The paper itself

Abstract

The Akt family is comprised of three unique homologous proteins with isoform-specific effects, but isoform-specific in vivo data are limited in follicular thyroid cancer (FTC), a PI3 kinase-driven tumor. Prior studies demonstrated that PI3K/Akt signaling is important in thyroid hormone receptor β

Indexed as

AnimalsDisease Models, AnimalDisease ProgressionFluorescent Antibody TechniqueGene Expression Regulation, NeoplasticMiceMice, KnockoutOligonucleotide Array Sequence AnalysisProtein IsoformsProto-Oncogene Proteins c-aktReceptors, Thyroid HormoneThyroid GlandThyroid NeoplasmsAkt1 protein, mouseAkt2 protein, mouseProtein IsoformsProto-Oncogene Proteins c-aktReceptors, Thyroid Hormone

Identifiers

PMID33110146
PMCPMC7591514
OpenAlexW3096230842

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.