ArticleScientific reports2020
Distributed changes of the functional connectome in patients with glioblastoma.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 44 citations in OpenAlex.
- Multiscale network perspectives on glioma: from tumour biology to symptoms, survival and treatment.Nature reviews. Neurology · 2026Review
- A non-local diffusion magnetic resonance imaging tract density biomarker to stratify, predict, and interpret survival rates in human glioblastoma.Neuro-oncology · 2026Article
- BOLD complexity characterizes glioblastoma survival via voxel-wise and localized sample entropy.Journal of neuro-oncology · 2026Article
- Changes in Somatomotor Network Connectivity Differentiate Better Versus Worse Recovery of Hand Dexterity After Brain Tumor Surgery: A Cohort Study.Neural plasticity · 2026Article
- Brain metabolic-functional (de)coupling from health to glioma dysfunction.Communications biology · 2025Article
- Neurocognitive and Resting-State Functional Magnetic Resonance Imaging Changes in Patients With Diffuse Gliomas After Chemoradiation Therapy.International journal of radiation oncology, biology, physics · 2025Article
- Predicting attention deficits and functional recovery after glioma resection through functional executive networks: insights from dynamic properties.Journal of neuro-oncology · 2025Article
- Spatio-Temporal Signatures of Cognitive Function After Pediatric Arterial Ischemic Stroke-A Pilot Study.Human brain mapping · 2025Article
- Article
- Quantification of brain functional connectivity deviations in individuals: A scoping review of functional MRI studies.NeuroImage. Clinical · 2025Article
- Assessment of Sports Concussion in Female Athletes: A Role for Neuroinformatics?Neuroinformatics · 2024Review
- Attention-Enhanced Fusion of Structural and Functional MRI for Analyzing HIV-Associated Asymptomatic Neurocognitive Impairment.Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention · 2024Article
- Functional and structural reorganization in brain tumors: a machine learning approach using desynchronized functional oscillations.Communications biology · 2024Article
- Predicting survival in glioblastoma with multimodal neuroimaging and machine learning.Journal of neuro-oncology · 2023Article
- Brain network mapping and glioma pathophysiology.Brain communications · 2023Review
- Machine learning in neuroimaging: from research to clinical practice.Radiologie (Heidelberg, Germany) · 2022Review
- Review
- Article
- Tumor-associated alterations in white matter connectivity have prognostic significance in MGMT-unmethylated glioblastoma.Journal of neuro-oncology · 2022Article
- Should Neurosurgeons Try to Preserve Non-Traditional Brain Networks? A Systematic Review of the Neuroscientific Evidence.Journal of personalized medicine · 2022Review
Corrections and comments
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Authors and funding
20 authors at 6 institutions in 3 countries.
Funding
Abstract
Glioblastoma might have widespread effects on the neural organization and cognitive function, and even focal lesions may be associated with distributed functional alterations. However, functional changes do not necessarily follow obvious anatomical patterns and the current understanding of this interrelation is limited. In this study, we used resting-state functional magnetic resonance imaging to evaluate changes in global functional connectivity patterns in 15 patients with glioblastoma. For six patients we followed longitudinal trajectories of their functional connectome and structural tumour evolution using bi-monthly follow-up scans throughout treatment and disease progression. In all patients, unilateral tumour lesions were associated with inter-hemispherically symmetric network alterations, and functional proximity of tumour location was stronger linked to distributed network deterioration than anatomical distance. In the longitudinal subcohort of six patients, we observed patterns of network alterations with initial transient deterioration followed by recovery at first follow-up, and local network deterioration to precede structural tumour recurrence by two months. In summary, the impact of focal glioblastoma lesions on the functional connectome is global and linked to functional proximity rather than anatomical distance to tumour regions. Our findings further suggest a relevance for functional network trajectories as a possible means supporting early detection of tumour recurrence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.