Evidence map›Paper›PMID 33110120›Full record

ArticleScientific reports2020

Interplay among p21

Emilia J Orzechowska, Takahito Katano, Agnieszka B Bialkowska, Vincent W Yang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Intestinal Epithelial Regeneration in Response to Ionizing Irradiation.Journal of visualized experiments : JoVE · 2022
    Article
  6. Aging of intestinal stem cells.Stem cell reports · 2022
    Review
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 3 countries.

Emilia J OrzechowskaDepartment of Medicine, Renaissance School of Medicine at Stony Brook University, Stony Brook, NY, USA.
Takahito KatanoDepartment of Medicine, Renaissance School of Medicine at Stony Brook University, Stony Brook, NY, USA.
Agnieszka B BialkowskaDepartment of Medicine, Renaissance School of Medicine at Stony Brook University, Stony Brook, NY, USA. Agnieszka.Bialkowska@stonybrookmedicine.edu.
Vincent W YangDepartment of Medicine, Renaissance School of Medicine at Stony Brook University, Stony Brook, NY, USA. Vincent.Yang@stonybrookmedicine.edu.
Stony Brook University · USStony Brook School · USUniversity of Warsaw · PL

Funding

REGULATION OF INTESTINAL EPITHELIAL CELL PROLIFERATIONR01DK052230 · NIDDK · STATE UNIVERSITY NEW YORK STONY BROOK · PI Vincent W Yang · 1997 to 2026
$8.7M
MECHANISMS OF INTESTINAL TUMORIGENESISR01CA084197 · NCI · STATE UNIVERSITY NEW YORK STONY BROOK · PI YANG, VINCENT W · 2000 to 2020
$7.5M
NCI NIH HHS R01 CA084197NIDDK NIH HHS R01 DK052230NIH HHS CA084197NIH HHS DK052230
6 · The paper itself

Abstract

Gamma radiation is a commonly used adjuvant treatment for abdominally localized cancer. Since its therapeutic potential is limited due to gastrointestinal (GI) syndrome, elucidation of the regenerative response following radiation-induced gut injury is needed to develop a preventive treatment. Previously, we showed that Krüppel-like factor 4 (KLF4) activates certain quiescent intestinal stem cells (ISCs) marked by Bmi1-Cre

Indexed as

AnimalsCyclin-Dependent Kinase Inhibitor p21Gamma RaysHEK293 CellsHumansIntestinal MucosaKruppel-Like Factor 4Kruppel-Like Transcription FactorsMiceNerve Tissue ProteinsPolycomb Repressive Complex 1Polymerase Chain ReactionProto-Oncogene ProteinsRadiation Injuries, ExperimentalRNA-Binding ProteinsStem CellsBmi1 protein, mouseCdkn1a protein, mouseCyclin-Dependent Kinase Inhibitor p21KLF4 protein, humanKlf4 protein, mouseKruppel-Like Factor 4Kruppel-Like Transcription FactorsMsi1h protein, mouseNerve Tissue ProteinsPolycomb Repressive Complex 1Proto-Oncogene ProteinsRNA-Binding Proteins

Identifiers

PMID33110120
PMCPMC7591575
OpenAlexW3094836345

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.