Evidence map›Paper›PMID 33110094›Full record

ArticleScientific reports2020

Pancreatic duct ligation reduces premalignant pancreatic lesions in a Kras model of pancreatic adenocarcinoma in mice.

Marta Cáceres, Rita Quesada, Mar Iglesias, Francisco X Real, Maria Villamonte, Jaime Martinez de Villarreal, Mónica Pérez, Ana Andaluz, Xavier Moll, Enrique Berjano and 4 more

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 1 country.

Marta CáceresDepartment of Surgery, Hospital del Mar, Barcelona, Spain.
Rita QuesadaDepartment of Surgery, Hospital del Mar, Barcelona, Spain.
Mar IglesiasDepartment of Surgery, Hospital del Mar, Barcelona, Spain.
Francisco X RealEpithelial Carcinogenesis Group, Molecular Oncology Programme, Centro Nacional de Investigaciones Oncológicas, Madrid, Spain.
Maria VillamonteDepartment of Surgery, Hospital del Mar, Barcelona, Spain.
Jaime Martinez de VillarrealEpithelial Carcinogenesis Group, Molecular Oncology Programme, Centro Nacional de Investigaciones Oncológicas, Madrid, Spain.
Mónica PérezEpithelial Carcinogenesis Group, Molecular Oncology Programme, Centro Nacional de Investigaciones Oncológicas, Madrid, Spain.
Ana AndaluzDepartament de Medicina i Cirurgia Animals, Facultat de Veterinària, Universitat Autònoma de Barcelona, Barcelona, Spain.
Xavier MollDepartament de Medicina i Cirurgia Animals, Facultat de Veterinària, Universitat Autònoma de Barcelona, Barcelona, Spain.
Enrique BerjanoBioMIT, Department of Electronic Engineering, Universitat Politècnica de València, Valencia, Spain.
Dimitri DorcarattoHospital Clínico de Valencia, Valencia, Spain.
Patricia Sánchez-VelázquezDepartment of Surgery, Hospital del Mar, Barcelona, Spain.
Luís GrandeDepartment of Surgery, Hospital del Mar, Barcelona, Spain.
Fernando BurdíoDepartment of Surgery, Hospital del Mar, Barcelona, Spain. fburdio@hotmail.com.
Hospital Del Mar · ESSpanish National Cancer Research Centre · ESUniversitat Autònoma de Barcelona · ESHospital Clínico Universitario de Valencia · ESUniversitat Politècnica de València · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pancreatic duct ligation (PDL) in the murine model has been described as an exocrine pancreatic atrophy-inducing procedure. However, its influence has scarcely been described on premalignant lesions. This study describes the histological changes of premalignant lesions and the gene expression in a well-defined model of pancreatic ductal adenocarcinoma by PDL. Selective ligation of the splenic lobe of the pancreas was performed in Ptf1a-Cre

Indexed as

AdenocarcinomaAged, 80 and overAnimalsDisease Models, AnimalFemaleGene Expression ProfilingHumansLigationMicePancreasPancreatic DuctsPancreatic NeoplasmsPrecancerous ConditionsProto-Oncogene Proteins p21(ras)Tissue Array AnalysisHras protein, mouseProto-Oncogene Proteins p21(ras)

Identifiers

PMID33110094
PMCPMC7591874
OpenAlexW3095122635

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.