Evidence map›Paper›PMID 33109779›Full record

ArticleAsian journal of andrology

Rossella Cannarella, Michele Salemi, Rosita A Condorelli, Laura Cimino, Giorgio Giurato, Giovanna Marchese, Angela Cordella, Corrado Romano, Sandro La Vignera, Aldo E Calogero

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Asian journal of andrology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Rossella CannarellaDepartment of Clinical and Experimental Medicine, University of Catania, Catania 95123, Italy.
Michele SalemiOasi Research Institute-IRCCS, Troina (EN) 94018, Italy.
Rosita A CondorelliDepartment of Clinical and Experimental Medicine, University of Catania, Catania 95123, Italy.
Laura CiminoDepartment of Clinical and Experimental Medicine, University of Catania, Catania 95123, Italy.
Giorgio GiuratoGenomix4Life Srl, Department of Medicine, Surgery and Dentistry "Schola Medica Salernitana," University of Salerno, Baronissi (SA) 84081, Italy.
Giovanna MarcheseGenomix4Life Srl, Department of Medicine, Surgery and Dentistry "Schola Medica Salernitana," University of Salerno, Baronissi (SA) 84081, Italy.
Angela CordellaGenomix4Life Srl, Department of Medicine, Surgery and Dentistry "Schola Medica Salernitana," University of Salerno, Baronissi (SA) 84081, Italy.
Corrado RomanoDepartment of Clinical and Experimental Medicine, University of Catania, Catania 95123, Italy.
Sandro La VigneraDepartment of Clinical and Experimental Medicine, University of Catania, Catania 95123, Italy.
Aldo E CalogeroDepartment of Clinical and Experimental Medicine, University of Catania, Catania 95123, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Klinefelter syndrome (KS) is the most common sex chromosome disorder in men. It is characterized by germ cell loss and other variable clinical features, including autoimmunity. The sex-determining region of Y (SRY)-box 13 (Sox13) gene is expressed in mouse spermatogonia. In addition, it has been identified as islet cell autoantigen 12 (ICA12), which is involved in the pathogenesis of autoimmune diseases, including type 1 diabetes mellitus (DM) and primary biliary cirrhosis. Sox13 expression has never been investigated in patients with KS. In this age-matched, case-control study performed on ten patients with KS and ten controls, we found that SOX13 is significantly downregulated in peripheral blood mononuclear cells of patients with KS compared to controls. This finding might be consistent with the germ cell loss typical of patients with KS. However, the role of Sox13 in the pathogenesis of germ cell loss and humoral autoimmunity in patients with KS deserves to be further explored.

Indexed as

AdultAutoantigensCase-Control StudiesDown-RegulationHumansKlinefelter SyndromeLeukocytes, MononuclearMaleSOXD Transcription FactorsYoung AdultAutoantigensSOX13 protein, humanSOXD Transcription Factorsgerm cellsintellectual disabilityKlinefelter syndromerare diseasesex-determining region of Y-box 13 (SOX13)

Identifiers

PMID33109779
PMCPMC7991811

What OpenQuestion holds

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LicenceCC BY-NC-SA
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.