ArticlemBio2020
A Small-Molecule Modulator of Metal Homeostasis in Gram-Positive Pathogens.
Open access · goldAbstract read
In one paragraph
Article in mBio, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 17 citations in OpenAlex.
- Mechanisms and Therapeutic Potential of Nutritional Immunity.Pathogens (Basel, Switzerland) · 2026Review
- Porphyrin pathways as targets for combating antimicrobial resistance: virulence and therapeutic opportunities.Frontiers in cellular and infection microbiology · 2026Review
- Syntheses and structures of dinuclear zinc(II) acetate-bridged coordination compounds with the aromatic Schiff base chelatorsActa crystallographica. Section E, Crystallographic communications · 2025Article
- Controllable self-cleaning FET self-assembled RNA-cleaving DNAzyme based DNA nanotree for culture-free Staphylococcus aureus detection.Journal of nanobiotechnology · 2024Article
- Bosutinib Stimulates Macrophage Survival, Phagocytosis, and Intracellular Killing of Bacteria.ACS infectious diseases · 2024Article
- Antibacterial insights into alternariol and its derivative alternariol monomethyl ether produced by a marine fungus.Applied and environmental microbiology · 2024Article
- Easy, Flexible and Standardizable Anti-Nascent Biofilm Activity Assay to Assess Implant Materials.Microorganisms · 2023Article
- Mitoxantrone targets both host and bacteria to overcome vancomycin resistance inScience advances · 2023Article
- A conserved zinc-binding site inProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Copper Intoxication in Group B Streptococcus Triggers Transcriptional Activation of theJournal of bacteriology · 2021Article
- Coordination Complexes to Combat Bacterial Infections: Recent Developments, Current Directions and Future Opportunities.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021Review
- Identification of Three Small Molecules That Can Selectively Influence Cellular Manganese Levels in a Mouse Striatal Cell Model.Molecules (Basel, Switzerland) · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 4 institutions in 1 country.
Lillian J Juttukonda *Vanderbilt Institute for Infection, Immunology and Inflammation, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
William N Beavers *Vanderbilt Institute for Infection, Immunology and Inflammation, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Daisy UnsihuayVanderbilt Institute for Infection, Immunology and Inflammation, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Kwangho KimChemical Synthesis Core, Vanderbilt University, Nashville, Tennessee, USA.
Gleb PishchanyDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, USA.
Kyle J HorningVanderbilt Brain Institute, Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Andy WeissVanderbilt Institute for Infection, Immunology and Inflammation, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Hassan Al-TameemiDepartment of Biochemistry and Microbiology, Rutgers, the State University of New Jersey, New Brunswick, New Jersey, USA.
Jeffrey M BoydDepartment of Biochemistry and Microbiology, Rutgers, the State University of New Jersey, New Brunswick, New Jersey, USA.ORCID 0000-0001-7721-3926
Gary A SulikowskiVanderbilt Institute for Infection, Immunology and Inflammation, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Aaron B BowmanVanderbilt Brain Institute, Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Eric P SkaarVanderbilt Institute for Infection, Immunology and Inflammation, Vanderbilt University Medical Center, Nashville, Tennessee, USA eric.skaar@vumc.org.
Vanderbilt University Medical Center · USVanderbilt University · USRutgers, The State University of New Jersey · USHarvard University · US
Funding
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007347 · NIGMS · VANDERBILT UNIVERSITY · PI WILLIAMS, CHRISTOPHER S. · 1985 to 2023
$26.3MTRAINING PROGRAM IN ENVIRONMENTAL TOXICOLOGYT32ES007028 · NIEHS · VANDERBILT UNIVERSITY · PI F PETER Guengerich, Fiona Edith Harrison · 1985 to 2026
$15.7MMechanisms of Manganese NeurotoxicityR01ES010563 · NIEHS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Michael Aschner, Aaron B Bowman · 2001 to 2026
$11.9MHost-mediated zinc sequestration during Acinetobacter baumannii infectionR01AI101171 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI WALTER J. CHAZIN, DAVID P. GIEDROC · 2013 to 2026
$8.2MPathobiology of heme inducible transporters in Gram positive pathogensR01AI073843 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI SKAAR, ERIC P · 2009 to 2025
$5.9MMechanism and function of heme-iron utilization in staphylococcal pathogenesisR01AI069233 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI SKAAR, ERIC P · 2006 to 2020
$5.6MMolecular mapping of microbial communities at the host-pathogen interface by multi-modal 3-dimensional imaging mass spectrometryR01AI138581 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Eric P Skaar, Jeffrey M Spraggins · 2018 to 2026
$5.2MThe Staphylococcus aureus response to nutrient zinc restriction during infectionR01AI150701 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI SKAAR, ERIC P · 2020 to 2024
$2.1MMechanisms of cellular respiration-dependent cell lysis and its impact on biofilm formation and disassembly in Staphylococcus aureus.R01AI139100 · NIAID · RUTGERS, THE STATE UNIV OF N.J. · PI BOYD, JEFF M · 2018 to 2022
$1.9MNIAID NIH HHS HHSN272200700055CNIAID NIH HHS R01 AI069233NIAID NIH HHS R01 AI073843NIAID NIH HHS R01 AI101171NIAID NIH HHS R01 AI138581NIAID NIH HHS R01 AI139100NIAID NIH HHS R01 AI150701NIEHS NIH HHS R01 ES010563NIEHS NIH HHS T32 ES007028NIGMS NIH HHS T32 GM007347
Abstract
Metals are essential nutrients that all living organisms acquire from their environment. While metals are necessary for life, excess metal uptake can be toxic; therefore, intracellular metal levels are tightly regulated in bacterial cells.
Indexed as
Anti-Bacterial AgentsCytoplasmGram-Positive BacteriaHomeostasisMetalsReactive Oxygen SpeciesSmall Molecule LibrariesStaphylococcus aureusVirulenceAnti-Bacterial AgentsMetalsReactive Oxygen SpeciesSmall Molecule LibrariesantibioticscobaltcoppermanganesemetalloregulationMRSAStaphylococcus aureus
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.