Evidence map›Paper›PMID 33109757›Full record

ArticlemBio2020

Population Analysis of Staphylococcus aureus Reveals a Cryptic, Highly Prevalent Superantigen SElW That Contributes to the Pathogenesis of Bacteremia.

Manouk Vrieling, Stephen W Tuffs, Gonzalo Yebra, Marleen Y van Smoorenburg, Joana Alves, Amy C Pickering, Joo Youn Park, Nogi Park, David E Heinrichs, Lindert Benedictus and 4 more

Open access · goldAbstract read
In one paragraph

Article in mBio, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.4field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Characterizing theJournal of bacteriology · 2025
    Article
  3. Article
  4. Pathogens (Basel, Switzerland) · 2025
    Review
  5. Review
  6. Article
  7. Review
  8. Review
  9. Review
  10. Prevalence and Virulence Determinants ofFoods (Basel, Switzerland) · 2022
    Article
  11. Superantigens promoteProceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  12. Article
  13. Ecology and Genetic Lineages of NasalPathogens (Basel, Switzerland) · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 3 countries.

Manouk Vrieling *The Roslin Institute, University of Edinburgh, Midlothian, United Kingdom.
Stephen W Tuffs *Department of Microbiology and Immunology, University of Western Ontario, London, Ontario, Canada.ORCID 0000-0002-2874-7822
Gonzalo YebraThe Roslin Institute, University of Edinburgh, Midlothian, United Kingdom.
Marleen Y van SmoorenburgThe Roslin Institute, University of Edinburgh, Midlothian, United Kingdom.
Joana AlvesThe Roslin Institute, University of Edinburgh, Midlothian, United Kingdom.
Amy C PickeringThe Roslin Institute, University of Edinburgh, Midlothian, United Kingdom.
Joo Youn ParkDepartment of Basic Sciences, College of Veterinary Medicine, Mississippi State University, Starkville, Mississippi, USA.
Nogi ParkDepartment of Basic Sciences, College of Veterinary Medicine, Mississippi State University, Starkville, Mississippi, USA.
David E HeinrichsDepartment of Microbiology and Immunology, University of Western Ontario, London, Ontario, Canada.ORCID 0000-0002-7217-2456
Lindert BenedictusThe Roslin Institute, University of Edinburgh, Midlothian, United Kingdom.
Timothy ConnelleyThe Roslin Institute, University of Edinburgh, Midlothian, United Kingdom.
Keun Seok SeoDepartment of Basic Sciences, College of Veterinary Medicine, Mississippi State University, Starkville, Mississippi, USA.ORCID 0000-0001-9280-9680
John K McCormickDepartment of Microbiology and Immunology, University of Western Ontario, London, Ontario, Canada.
J Ross FitzgeraldThe Roslin Institute, University of Edinburgh, Midlothian, United Kingdom ross.fitzgerald@ed.ac.uk.ORCID 0000-0002-9233-8468
Roslin Institute · GBMississippi State University · USWestern University · CA

Funding

Training and Mentoring Core P20GM103476 · NIGMS · UNIVERSITY OF SOUTHERN MISSISSIPPI · PI MICHAEL R GARRETT · 2012 to 2026
$60.2M
Zinc dependent conformational changes in AdcR and their impact on DNA bindingP20GM103646 · NIGMS · MISSISSIPPI STATE UNIVERSITY · PI THIBAUDEAU, GISELLE · 2013 to 2022
$21.1M
Biotechnology and Biological Sciences Research Council BBS/E/D/20002173Biotechnology and Biological Sciences Research Council BBS/E/D/20002174CIHR PJT-153308CIHR PJT-166050Medical Research Council MR/N02995X/1NIGMS NIH HHS P20 GM103476NIGMS NIH HHS P20 GM103646Wellcome TrustWellcome Trust 201531/Z/16/Z
6 · The paper itself

Abstract

Staphylococcal superantigens (SAgs) are a family of secreted toxins that stimulate T cell activation and are associated with an array of diseases in humans and livestock. Most SAgs produced by

Indexed as

AnimalsBacteremiaBacterial LoadFemaleGene DeletionGenomicsHumansLiverLymphocyte ActivationMiceMice, Inbred C57BLMice, TransgenicStaphylococcal InfectionsStaphylococcus aureusSuperantigensSuperantigensevolutionpathogenesisStaphylococcus aureussuperantigensT cells

Identifiers

PMID33109757
PMCPMC7593966
OpenAlexW3097151670

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.