ArticleScience signaling2020
Modulation of PKM activity affects the differentiation of T
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Article in Science signaling, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
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Who cites it
25 citing papers in PubMed, 36 citations in OpenAlex.
- Targeting pyruvate kinase M2 (PKM2) reduces T cell pathogenicity in multiple sclerosis.EBioMedicine · 2026Article
- Exploration and analysis of methylglyoxal-driven chronic inflammation in polycystic ovary syndrome.Journal of advanced research · 2026Article
- ASO-based PKM splice-switching therapy increases anti-CTLA-4 antibody efficacy in pancreatic ductal adenocarcinoma.Cell discovery · 2026Article
- Pyruvate kinase muscle 2 (PKM2) promotes CD4 T cell survival by regulating pyruvate oxidation during homeostasis and expansion.Science advances · 2026Article
- The E3 ligases Itch and WWP2 regulate autoimmune neuroinflammation by controlling TNature communications · 2026Article
- CCL20-CCR6 signaling alters the metabolic reprogramming to promote the pathogenic Th17 cell differentiation.iScience · 2026Article
- Cellular Distribution of Pyruvate Kinase M2 After Spinal Cord Injury in Adult Rats.Molecular neurobiology · 2025Article
- Immune cell metabolic reprogramming in hepatocellular carcinoma: mechanisms, tumor microenvironment, and future immunotherapeutic directions.Frontiers in immunology · 2025Review
- The critical role of Th17 cells and IL-17A in autoimmune and inflammation-associated neurological diseases: mechanisms and therapeutic perspectives.Frontiers in immunology · 2025Review
- MTX2 facilitates PKM2 tetramerization to promote cardiac glucose metabolism and protects the heart against ischemia/reperfusion injury.Theranostics · 2025Article
- Deficiency of metabolic regulator PKM2 activates the pentose phosphate pathway and generates TCF1Nature immunology · 2024Article
- Emerging roles of lactate in acute and chronic inflammation.Cell communication and signaling : CCS · 2024Review
- Imbalance in Glucose Metabolism Regulates the Transition of Microglia from Homeostasis to Disease-Associated Microglia Stage 1.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Targeting pyruvate kinase M2 for the treatment of kidney disease.Frontiers in pharmacology · 2024Review
- T cell metabolism in kidney immune homeostasis.Frontiers in immunology · 2024Review
- Article
- Identification of protein-protein interaction bridges for multiple sclerosis.Bioinformatics (Oxford, England) · 2023Article
- Stress-induced despair behavior develops independently of the Ahr-RORγt axis in CD4 + cells.Scientific reports · 2022Article
- Sulforaphane diminishes moonlighting of pyruvate kinase M2 and interleukin 1β expression in M1 (LPS) macrophages.Frontiers in immunology · 2022Article
- PD-1 Targeted Nanoparticles Inhibit Activated T Cells and Alleviate Autoimmunity via Suppression of Cellular Energy Metabolism Mediated by PKM2.International journal of nanomedicine · 2022Article
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Authors and funding
14 authors at 1 institution in 1 country.
Scott M SekiCenter for Brain Immunology and Glia, Department of Neuroscience, University of Virginia, Charlottesville, VA 22908, USA.ORCID 0000-0002-2112-0672
Kacper PosyniakCenter for Brain Immunology and Glia, Department of Neuroscience, University of Virginia, Charlottesville, VA 22908, USA.ORCID 0000-0003-4070-1330
Rebecca McCloudDepartment of Chemistry, University of Virginia, Charlottesville, VA 22908, USA.ORCID 0000-0002-0053-0883
Dorian A RosenCenter for Brain Immunology and Glia, Department of Neuroscience, University of Virginia, Charlottesville, VA 22908, USA.ORCID 0000-0002-0342-8454
Anthony Fernández-CastañedaCenter for Brain Immunology and Glia, Department of Neuroscience, University of Virginia, Charlottesville, VA 22908, USA.ORCID 0000-0002-0416-442X
Rebecca M BeiterCenter for Brain Immunology and Glia, Department of Neuroscience, University of Virginia, Charlottesville, VA 22908, USA.ORCID 0000-0002-0756-6037
Vlad SerbuleaGraduate Program in Pharmacological Sciences, University of Virginia, Charlottesville, VA 22908, USA.ORCID 0000-0002-9988-4410
Sarah C NanziriCenter for Brain Immunology and Glia, Department of Neuroscience, University of Virginia, Charlottesville, VA 22908, USA.ORCID 0000-0002-3995-0463
Nikolas HayesCenter for Brain Immunology and Glia, Department of Neuroscience, University of Virginia, Charlottesville, VA 22908, USA.ORCID 0000-0003-1885-1850
Charles SpiveyCenter for Brain Immunology and Glia, Department of Neuroscience, University of Virginia, Charlottesville, VA 22908, USA.ORCID 0000-0003-2706-8075
Lelisa GemtaDepartment of Microbiology, Immunology and Cancer Biology, University of Virginia, Charlottesville, VA 22908, USA.ORCID 0000-0001-8234-1738
Timothy N J BullockDepartment of Microbiology, Immunology and Cancer Biology, University of Virginia, Charlottesville, VA 22908, USA.ORCID 0000-0001-6141-3261
Ku-Lung HsuDepartment of Chemistry, University of Virginia, Charlottesville, VA 22908, USA.ORCID 0000-0001-5620-3972
Alban GaultierCenter for Brain Immunology and Glia, Department of Neuroscience, University of Virginia, Charlottesville, VA 22908, USA. ag7h@virginia.edu.ORCID 0000-0002-4175-6053
University of Virginia · US
Funding
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007267 · NIGMS · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI GARCIA-BLANCO, MARIANO A. · 1985 to 2024
$13.4MTRAINING IN THE PHARMACOLOGICAL SCIENCEST32GM007055 · NIGMS · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI LYNCH, KEVIN R. · 1985 to 2022
$7.2MPREDOCTORAL TRAINING IN NEUROSCIENCET32GM008328 · NIGMS · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI LEE, KEVIN SCOTT · 1992 to 2017
$3.9MRole of LRP1 in NF-kB mediated neuroinflammationR01NS083542 · NINDS · UNIVERSITY OF VIRGINIA · PI GAULTIER, ALBAN P · 2015 to 2019
$1.9MMeningeal immunity - a middleman between gut microbiome and the brainR33MH108156 · NIMH · UNIVERSITY OF VIRGINIA · PI GAULTIER, ALBAN P, KIPNIS, JONATHAN · 2017 to 2019
$1.3MMeningeal immunity - a middleman between gut microbiome and the brainR21MH108156 · NIMH · UNIVERSITY OF VIRGINIA · PI GAULTIER, ALBAN P, KIPNIS, JONATHAN · 2015 to 2016
$541kTargeting metabolic vulnerabilities of immune cells to treat CNS demyelinationF31NS103327 · NINDS · UNIVERSITY OF VIRGINIA · PI SEKI, SCOTT M · 2017 to 2017
$29kNIGMS NIH HHS T32 GM007055NIGMS NIH HHS T32 GM007267NIGMS NIH HHS T32 GM008328NIMH NIH HHS R21 MH108156NIMH NIH HHS R33 MH108156NINDS NIH HHS F31 NS103327NINDS NIH HHS R01 NS083542
Abstract
Small molecules that promote the metabolic activity of the pyruvate kinase isoform PKM2, such as TEPP-46 and DASA-58, limit tumorigenesis and inflammation. To understand how these compounds alter T cell function, we assessed their therapeutic activity in a mouse model of T cell-mediated autoimmunity that mimics multiple sclerosis (MS). T
Indexed as
AnimalsCell DifferentiationFemaleMaleMiceMice, KnockoutMultiple SclerosisPyridazinesPyrrolesPyruvate KinaseSignal TransductionTh17 CellsTransforming Growth Factor beta1ML-265Pkm protein, mousePyridazinesPyrrolesPyruvate KinaseTgfb1 protein, mouseTransforming Growth Factor beta1
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.