Evidence map›Paper›PMID 33109687›Full record

ArticleMolecular pharmacology2021

Identification of the Functional Binding Site for the Convulsant Tetramethylenedisulfotetramine in the Pore of the

Brandon Pressly, Ruth D Lee, Bogdan Barnych, Bruce D Hammock, Heike Wulff

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. The seizure-inducing plastic explosive RDX inhibits the α1β2γ2 GABAAnnals of clinical and translational neurology · 2022
    Article
  2. Article
  3. The efficacy of γ-aminobutyric acid type A receptor (GABAToxicology and applied pharmacology · 2021
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Brandon PresslyDepartments of Pharmacology (B.P., R.D.L, H.W.) and Entomology and Nematology, and Comprehensive Cancer Center (B.B., B.D.H.), University of California, Davis, California.
Ruth D LeeDepartments of Pharmacology (B.P., R.D.L, H.W.) and Entomology and Nematology, and Comprehensive Cancer Center (B.B., B.D.H.), University of California, Davis, California.
Bogdan BarnychDepartments of Pharmacology (B.P., R.D.L, H.W.) and Entomology and Nematology, and Comprehensive Cancer Center (B.B., B.D.H.), University of California, Davis, California.
Bruce D HammockDepartments of Pharmacology (B.P., R.D.L, H.W.) and Entomology and Nematology, and Comprehensive Cancer Center (B.B., B.D.H.), University of California, Davis, California.
Heike WulffDepartments of Pharmacology (B.P., R.D.L, H.W.) and Entomology and Nematology, and Comprehensive Cancer Center (B.B., B.D.H.), University of California, Davis, California hwulff@ucdavis.edu.
University of California, Davis · US

Funding

Training and Education CoreU54NS079202 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI LEIN, PAMELA J · 2012 to 2021
$35.7M
Supplement for bioactive lipids as effectors and indicators of the deleterious effects of human healthR35ES030443 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI MORISSEAU, CHRISTOPHE HP · 2019 to 2025
$5.8M
Predoctoral Training in Pharmacological SciencesT32GM099608 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HELL, JOHANNES W · 2012 to 2021
$2.2M
Identifying Molecular Targets for the Proconvulsant Activity of TETSR21NS110647 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI LEIN, PAMELA J, WULFF, HEIKE · 2019 to 2020
$414k
NIEHS NIH HHS R35 ES030443NIGMS NIH HHS T32 GM099608NINDS NIH HHS R21 NS110647NINDS NIH HHS U54 NS079202
6 · The paper itself

Abstract

Tetramethylenedisulfotetramine (TETS) is a so-called "caged" convulsant that is responsible for thousands of accidental and malicious poisonings. Similar to the widely used GABA receptor type A (GABA

Indexed as

Binding SitesBridged-Ring CompoundsConvulsantsDose-Response Relationship, DrugHumansProtein Structure, SecondaryProtein Structure, TertiaryReceptors, GABA-ABridged-Ring CompoundsConvulsantsGABRA2 protein, humanGABRB3 protein, humanGABRG2 protein, humanReceptors, GABA-Atetramethylenedisulfotetramine

Identifiers

PMID33109687
PMCPMC7746976
OpenAlexW3096198182

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.