ArticleBMJ open2020
The Brabant study: design of a large prospective perinatal cohort study among pregnant women investigating obstetric outcome from a biopsychosocial perspective.
Article in BMJ open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Returning to work after maternity leave: a systematic literature review.Archives of women's mental health · 2024Pooled it
- A cross-lagged panel model examining the longitudinal associations between maternal emotion regulation difficulties, parenting stress, and child socio-emotional problems in toddlerhood.Infant mental health journal · 2026Article
- Trajectories of maternal bonding over the perinatal period: Associations with demographic, obstetric, psychological, and infant variables.Infant mental health journal · 2026Article
- Identifying prenatal risk factors of postpartum depression with machine learning.Scientific reports · 2025Article
- Inflammatory markers in pregnancy - identifying drivers in four large cohorts.Frontiers in immunology · 2025Article
- Hypothyroxinaemia during gestation is associated with low ferritin and increased levels of inflammatory markers.European thyroid journal · 2024Article
- Maternal perinatal depression and child neurocognitive development: A relationship still to be clarified.Frontiers in psychiatry · 2023Article
- Implementing "Online Communities" for pregnant women in times of COVID-19 for the promotion of maternal well-being and mother-to-infant bonding: a pretest-posttest study.BMC pregnancy and childbirth · 2022Article
- Perinatal depression screening and prevention: Descriptive findings from a multicentric program in the South of Italy.Frontiers in psychiatry · 2022Article
- The COVID-19 outbreak increases maternal stress during pregnancy, but not the risk for postpartum depression.Archives of women's mental health · 2021Article
- Development of the COVID-19 Perinatal Perception Questionnaire (COVID19-PPQ).Journal of psychopathology and behavioral assessment · 2021Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPregnancy is characterised by many biological and psychosocial changes. Adequate maternal thyroid function is important for the developing fetus throughout gestation. Latent class analyses recently showed three different patterns of change in thyroid function throughout pregnancy with different associations with obstetric outcome. Maternal distress during the pregnancy (anxiety and depression) negatively affects obstetric outcome. Pregnancy distress in turn may be affected by personality traits and attachment styles. Moreover, during the pregnancy, substantial social changes occur in the partner relationship and work experience. The aim of the Brabant study is to investigate the association between thyroid function trajectories and obstetric outcomes. Moreover, within the Brabant study, we will investigate how different trajectories of pregnancy distress are related to obstetric outcome, and the role of personality in this association. We will evaluate the possible role of maternal distress and attachment style on maternal-fetal bonding. Finally, we will study social changes in the perinatal period regarding partner relationship and well-being and performance at work. METHODS AND ANALYSIS: The Brabant study is a longitudinal, prospective cohort study of an anticipated 4000 pregnant women. Women will be recruited at 8-10 weeks gestation among community midwife practices in South-East Brabant in the Netherlands. Thyroid function parameters (TSH and fT4), thyroid peroxidase antibody and human chorionic gonadotrophin will be assessed at 12, 20 and 28 weeks gestation. Moreover, at these three time points women will fill out questionnaires assessing demographic and obstetric features, life style habits and psychological and social variables, such as depressive symptoms, personality, partner relationship quality and burnout. Data from the obstetric records will also be collected. ETHICS AND DISSEMINATION: The study has been approved by the Medical Ethical Committee of the Máxima Medical Center Veldhoven. Results will be submitted to peer-reviewed journals in the relevant fields and presented on national and international conferences.
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