ArticleRMD open2020
High body mass index is associated with increased risk for osteoarthritis of the first carpometacarpal joint during more than 30 years of follow-up.
Article in RMD open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 28 citations in OpenAlex.
- Article
- Chronic corticosteroid use does not increase short-term complications following carpometacarpal arthroplasty.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2024Article
- Risk of hand and forearm conditions due to vibrating hand-held tools exposure: a retrospective cohort study from Sweden.BMJ open · 2024Article
- Association of Weight Loss and Weight Gain With Structural Defects and Pain in Hand Osteoarthritis: Data From the Osteoarthritis Initiative.Arthritis care & research · 2024Article
- Deep learning for synovial volume segmentation of the first carpometacarpal joint in osteoarthritis patients.Osteoarthritis imaging · 2024Article
- Body Mass Index as a Predictor for Postoperative Complications Following Carpometacarpal Arthroplasty.Journal of hand surgery global online · 2023Article
- Macrophage-Driven Inflammation in Metabolic Osteoarthritis: Implications for Biomarker and Therapy Development.International journal of molecular sciences · 2023Review
- Familial Clustering and Genetic Analysis of Severe Thumb Carpometacarpal Joint Osteoarthritis in a Large Statewide Cohort.The Journal of hand surgery · 2022Article
- Diabetic hand: prevalence and incidence of diabetic hand problems using data from 1.1 million inhabitants in southern Sweden.BMJ open diabetes research & care · 2022Article
- Current Epidemiology and Risk Factors for the Development of Hand Osteoarthritis.Current rheumatology reports · 2021Review
- [The effect of obesity on disease activity of inflammatory rheumatic diseases].Zeitschrift fur Rheumatologie · 2021Review
- Diet, body weight and pain susceptibility - A systematic review of preclinical studies.Neurobiology of pain (Cambridge, Mass.)Review
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionOsteoarthritis (OA) of the first carpometacarpal (CMC-1) joint is a common hand disorder with symptoms including pain and weakness of the thumb. Previous studies have associated high BMI with OA of weight-bearing joints, whereas studies regarding non-weight-bearing joints have shown conflicting results. Thus, the aim of this study was to investigate the influence of overweight and obesity on incident OA of the CMC-1 joint.
methodDuring 1974 to 1992, 33 346 participants aged 26-61 years were included in the population-based cohort Malmö Preventive Project. Endpoint data were retrieved from Swedish national registers until end of 2018. Sex-stratified Cox regression models adjusted for potential confounders were calculated using BMI as a continuous variable and stratified for normal weight, overweight and obesity.
resultsMedian follow-up was 36 years for men and 32 years for women. A one-unit increment of BMI was independently associated with incident OA of the CMC-1 joint in men (HR 1.12; 95% CI 1.09 to 1.15, p<0.001) and women (HR 1.05; 95% CI 1.03 to 1.08, p<0.001). Stratifying for BMI groups, obesity was independently associated with OA of the CMC-1 joint in men (HR 3.57; 95% CI 2.68 to 4.77, p<0.001) and women (HR 1.98; 95% CI 1.44 to 2.73, p<0.001).
conclusionHigh BMI and obesity are major risk factors for OA of the CMC-1 joint. The association was stronger among men but could be demonstrated also among women. Future studies are warranted to clarify underlying pathophysiological mechanisms for this association, enabling identification of potential therapeutic targets related to obesity in order to prevent the development of OA of the CMC-1 joint.
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