SynthesisStroke and vascular neurology2021
Effects of vitamin E on stroke: a systematic review with meta-analysis and trial sequential analysis.
Synthesis in Stroke and vascular neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 4 syntheses or guidelines pooled it, 81 citations in OpenAlex.
- Dietary total antioxidant capacity and risk of stroke: a systematic review and dose-response meta-analysis of observational studies.Frontiers in nutrition · 2024Pooled it
- Pooled it
- The impact of triglyceride-glucose index on ischemic stroke: a systematic review and meta-analysis.Cardiovascular diabetology · 2023Pooled it
- Vitamin E intake and multiple health outcomes: an umbrella review.Frontiers in public health · 2023Pooled it
- α-tocopherol in the prevention of ischemic or hemorrhagic stroke: A meta-analysis.Experimental and therapeutic medicine · 2026Article
- The prognostic value of the PALBI score for mortality prediction in stroke: an internal and external validation study.Scientific reports · 2026Article
- Utility of Novel Lipid Parameters for Risk Stratification in Patients with Diabetes and STEMI-from a Prospective Study.Vascular health and risk management · 2026Article
- From diet to brain repair: natural bioactive compounds in post-ischemic stroke recovery.Frontiers in nutrition · 2026Review
- Body Representation in Stroke Patients: A Systematic Review of Human Figure Graphic Representation.Journal of clinical medicine · 2025Review
- Association between stress hyperglycemia ratio (SHR) and long-term mortality in patients with ischemic stroke: a retrospective cohort study.Cardiovascular diabetology · 2025Article
- Metabolic dysfunction-associated steatotic liver disease in adults.Nature reviews. Disease primers · 2025Review
- The association between visceral fat metabolic score and stroke: mediation by declining kidney function.Diabetology & metabolic syndrome · 2025Article
- Vitamin E (α-Tocopherol): Emerging Clinical Role and Adverse Risks of Supplementation in Adults.Cureus · 2025Review
- Multivitamin supplementation as a potential adjunctive therapy in post-cardiac arrest: insights from a multicenter retrospective analysis of MIMIC-IV and eICU-CRD.Frontiers in nutrition · 2025Article
- Neutrophil-related immune-inflammatory biomarkers influence the early progression of medial medullary infarction.Frontiers in neurology · 2025Article
- The Influence of Oxidative Stress Markers in Patients with Ischemic Stroke.Biomolecules · 2024Review
- Oxidative Stress and Cerebral Vascular Tone: The Role of Reactive Oxygen and Nitrogen Species.International journal of molecular sciences · 2024Review
- Identification of hypoxia- and immune-related biomarkers in patients with ischemic stroke.Heliyon · 2024Article
- Antioxidants and the risk of stroke: results from NHANES and two-sample Mendelian randomization study.European journal of medical research · 2024Article
- The Multitarget Action of Vitamins in the Ischemic Stroke.Current topics in medicinal chemistry · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There are several previous studies on the association of vitamin E with prevention of stroke but the findings remain controversial. We have conducted a systematic review, meta-analysis together with trial sequential analysis of randomised controlled trials to evaluate the effect of vitamin E supplementation versus placebo/no vitamin E on the risk reduction of total, fatal, non-fatal, haemorrhagic and ischaemic stroke. Relevant studies were identified by searching online databases through Medline, PubMed and Cochrane Central Register of Controlled Trials. A total of 18 studies with 148 016 participants were included in the analysis. There was no significant difference in the prevention of total stroke (RR (relative risk)=0.98, 95% CI 0.92-1.04, p=0.57), fatal stroke (RR=0.96, 95% CI 0.77-1.20, p=0.73) and non-fatal stroke (RR=0.96, 95% CI 0.88-1.05, p=0.35). Subgroup analyses were performed under each category (total stroke, fatal stroke and non-fatal stroke) and included the following subgroups (types of prevention, source and dosage of vitamin E and vitamin E alone vs control). The findings in all subgroup analyses were statistically insignificant. In stroke subtypes analysis, vitamin E showed significant risk reduction in ischaemic stroke (RR=0.92, 95% CI 0.85-0.99, p=0.04) but not in haemorrhagic stroke (RR=1.17, 95% CI 0.98-1.39, p=0.08). However, the trial sequential analysis demonstrated that more studies were needed to control random errors. Limitations of this study include the following: trials design may not have provided sufficient power to detect a change in stroke outcomes, participants may have had different lifestyles or health issues, there were a limited number of studies available for subgroup analysis, studies were mostly done in developed countries, and the total sample size for all included studies was insufficient to obtain a meaningful result from meta-analysis. In conclusion, there is still a lack of statistically significant evidence of the effects of vitamin E on the risk reduction of stroke. Nevertheless, vitamin E may offer some benefits in the prevention of ischaemic stroke and additional well-designed randomised controlled trials are needed to arrive at a definitive finding. PROSPERO registration number: CRD42020167827.
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Registered trials
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